Objective To analyze serum levels of interleukin-17(IL-17), interleukin-36 (IL-36) and eosinophil (EOS) count in children with bronchial asthma, and to discuss the clinical significance. Methods Totally 65 children with asthma were enrolled from July 2017 to July 2018 in Weifang People′s Hospital, of whom 30 cases were in acute exacerbation, 35 cases were in remission, and 25 health children were as control group. The serum levels of IL-17 and IL-36 were detected by enzyme-linked immunosorbent assay (ELISA), the eosinophil count in peripheral blood was measured by hematology analyzer, and the statistical analysis was performed. Results 1) The serum levels of IL-17 in acute exacerbation group[(45.73±8.86)pg/ml] and remission group[(21.06±5.51)pg/ml] were significantly higher than that in control group[(7.29±4.29)pg/ml] (P<0.01), and serum levels of IL-17 in acute exacerbation group was significantly higher than that in remission group(P<0.01). 2) The serum levels of IL-36 in acute exacerbation group[(53.76±10.60)pg/ml ] and remission group [(24.45±6.59) pg/ml] were significantly higher than that in control group[(8.46±4.86) pg/ml] (P<0.01), and serum level of IL-36 in acute exacerbation group was significantly higher than those in remission group(P<0.01). 3) In asthma children, serum level of IL-17 were positively correlated with the level of IL-36(P<0.01), and significant correlation were noted between the serum levels of IL-17, IL-36 and EOS count (P<0.01). Conclusion IL-17 and IL-36 are all involved in the pathogenesis of serum asthma in children, and serum levels of IL-17 and IL-36 may become a good biomarker for the diagnosis and evaluation of severity of asthma children.
Key words
bronchial asthma /
interleukin-17 /
interleukin-36 /
eosinophil /
children
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