Objective To observe the effect of different intensities of exercise training on learning and memory of adolescent rats,as well as the relationship between training and serum leptin levels. Methods Totally 30 rats aged 45-50 days were selected and randomly divided into three groups,including low intensity exercise,moderate intensity exercise and control group,with 10 rats in each group. Morris water maze was used to observe the learning and memory of rats. The serum leptin level was tested by enzyme-linked immunosorbent assay (ELISA). Results The average escape latency of four morris water maze tests in the moderate intensity exercise was (44.8±5.0) s,(49.3±5.2) s,(39.3±4.7) s and (37.7±2.8) s,respectively,which were all shorter than those of control group(P＜0.01). The number of crossing platform and the level of serum leptin in the moderate intensity exercise training group were significantly higher than those in normal group (15.1±4.5) pg/ml vs. (12.8±3.7) pg/ml,5.2±1.8 vs. 2.6±0.4,P<0.05). Conclusion Moderate intensity exercise training can improve learning and memory ability of adolescent rats,which may be related to the increase of serum leptin content.
Key words
learning and memory /
exercise training /
leptin /
adolescent rats
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