Objective To investigate the application of amplitude integrated electroencephalogram (aEEG) in early diagnosis of white-matter damage in late preterm infants and its correlation with short-term prognosis of nerve system,in order to provide reference for the treatment of brain damage in preterm infants. Methods Totally 146 late preterm infants with gestational age of 34-37 weeks in Neonatal Intensive Care Unit of the Third Affiliated Hospital of Anhui Medical University were enrolled in this study from January 2016 to June 2017.The participants were divided into white-matter damage (WMD) group (observation group,66 cases) and control group (80 cases) according to the Results of MRI result.The features of aEEG,including continuity (Co),sleep-wake cycling (Cy),amplitude of the lower border (LB),bandwidth span (B),total scores (T) and the difference with the mean total CFM scores were evaluated and compared between the two groups.The diagnosis value of each score index in WMD infants and the correlation of the Results of aEEG with brain MRI and Gesell Developmental Scale(GDS) score at corrected age of 12 months were analyzed. Results Cy,B,T scores were significantly lower in white-matter damage infants,while the differential value of aEEG score in white matter damage infants was signifincantly higher(P<0.05).The Results of brain MRI were correlated with Cy,LB,B and total scores(r=-0.261,-0.271,-0.253,-0.184,P<0.05).Chi-square test analysis indicated that the aEEG monitoring Results were related to cranial MRI examination (χ2=5.547,P=0.014),so was the relationship between aEEG monitoring Results and GDS score (χ2=5.979,P=0.014). Conclusions aEEG monitoring is of good diagnostic value for early white-matter damage in late preterm infants,and it can evaluate the short-term prognosis of preterm infants effectively.
Key words
amplitude-integrated electroencephalogram /
preterm infant /
white-matter damage /
prognosis
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