Meta analysis on the correlation between the history of female cancer and neonatal birth outcome

HUANG Feng-yan; GAO Han; WANG Zhi-ping

doi:10.11852/zgetbjzz2018-1148

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (6) : 633-636. DOI: 10.11852/zgetbjzz2018-1148

Meta analysis on the correlation between the history of female cancer and neonatal birth outcome

HUANG Feng-yan, GAO Han, WANG Zhi-ping

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Abstract

Objective To evaluate the risk of adverse pregnancy outcomes in female cancer survivors by systematic review and meta-analysis,in order to provide reference for the development of maternity protection technologies for cancer survivors. Methods Articles regarding adverse pregnancy outcomes in neonates born to female cancer survivors from January 1st,2008 to August 1st,2018,published in the Web of Science database and PubMed,were retrieved.Newcastle-Ottawa Scale (NOS) standard was used for literature quality evaluation.Outcomes included premature birth,low birth weight,congenital malformations,small for gestational age (SGA) infants and live birth.The heterogeneity test was carried out on the included literature,and the fixed effect model or the random effect model was used to perform the Meta analysis and to calculate the combined effect value according to the heterogeneity test result.Sensitivity analysis was performed using the one-by-one culling method.The publication bias of the research literature was evaluated using the Begg test and the Egger test. Results Finally 12 articles were included.According to the heterogeneity test results,the randomized effect model indicated that the combined RR (95% CI) values of premature delivery,congenital malformation in children,and live births in children born by cancer survivors were 2.058 (1.337-3.169)(P＜0.001),0.929 (0.676-1.277) (P=0.650),0.852 (0.756-0.960) (P=0.008),respectively.The fixed effect model showed that the combined RR (95% CI) values of SGA and low birth weight infants born to mothers with childhood cancer survivors were 1.563 (1.386-1.763) (P＜0.001),1.017 (0.859-1.205) (P=0.843). Conclusions Female cancer survivors have an increasing risk of preterm birth,low birth weight infants and stillbirths.However,the history of female cancer is not significantly associated with congenital malformations and SGA risk in neonates.

Key words

history of cancer / premature birth / low birth weight / congenital malformation / small for gestational age infant / live birth

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HUANG Feng-yan, GAO Han, WANG Zhi-ping. Meta analysis on the correlation between the history of female cancer and neonatal birth outcome[J]. Chinese Journal of Child Health Care. 2019, 27(6): 633-636 https://doi.org/10.11852/zgetbjzz2018-1148

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