Objective To evaluate the effect of music therapy on children with autism spectrum disorder (ASD) systematically, in order to provide evidence for further rehabilitation of ASD children. Methods Randomized controlled trial studies on the effect of music therapy on ASD children from 2000 to 2017 were analyzed by Meta-analysis with Rev Man 5.3 software. The fixed effect model or random effect model was selected by the heterogeneity test results. The SMD value and 95%CI were calculated, publication bias was evaluated, and sensitivity analysis was conducted. Subgroup analysis was conducted according to different duration time of intervention. Results Totally 20 published articles were selected, including 614 intervention cases and 622 control cases. The values of SMD and 95%CI of music therapy for overall effect of ASD children were of statistical significance(SMD=－0.74, 95%CI:－1.14－－0.34, P＜0.001). Also, music therapy improved social interaction skills(SMD=－0.81, 95%CI:－1.08－－0.54, P＜0.001), language function(SMD=－0.57,95%CI:－0.84－－0.29, P＜0.001) and language communication(SMD= 0.92,95%CI:0.41－1.44,P＜0.001)of ASD children significantly except for social behaviors (SMD=－0.85,95%CI:－0.61-0.03,P＞0.05). Subgroup analysis showed that music therapy did not significantly improve non-language communication skills of ASD children(SMD=0.45,95%CI:－0.11－1.01,P=0.12). Conclusions Music therapy has positive effect on core symptoms of ASD children, including the overall effect, social interaction, language function and language communication. However, it is suggested to combine music therapy with other comprehensive intervention and education interventions instead of conducting music therapy alone. Meanwhile, individualized and comprehensive interventions are expected according to the different symptoms of ASD children, in order to promote their better rehabilitation.
Key words
music therapy /
autism spectrum disorder /
randomized controlled trials /
Meta-analysis
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