Advance on insulin-like growth factor-1 in autism spectrum disorders

HONG Xiao-wen; CHEN Yan-hui

doi:10.11852/zgetbjzz2018-1095

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (1) : 56-58. DOI: 10.11852/zgetbjzz2018-1095

Advance on insulin-like growth factor-1 in autism spectrum disorders

HONG Xiao-wen, CHEN Yan-hui

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Abstract

The diagnosis of autism spectrum disorder (ASD) is mainly dependent on behavioral symptoms,and most children could not receive accurate diagnosis until 4 years old when the impairment of social interaction presents typically and the best period of intervention has been missed. It is worth noting that scientists have made a lot of theoretical and practical research on the pathological mechanism and drug target of ASD. And more and more studies have shown that the biomarker,insulin-like growth factor-1 (IGF-1),plays an important role in the development and progression in ASD. This review will summarize the role of IGF-1 in ASD in order to elucidate that IGF-1 is expected to be a biomarker of early diagnosis and early prevention of ASD,and to explore the application of IGF-1.

Key words

autism spectrum disorder / insulin-like growth factor-1 / SHANK3 gene / Engrailed2 gene / MECP2 protein

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HONG Xiao-wen, CHEN Yan-hui. Advance on insulin-like growth factor-1 in autism spectrum disorders[J]. Chinese Journal of Child Health Care. 2019, 27(1): 56-58 https://doi.org/10.11852/zgetbjzz2018-1095

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