Objective To analyze levels of serum amyloid A(SAA)and human cartilage glycoprotein-39(HC-gp39) in children with mycoplasma pneumonia(MP),as well as the correlation with efficacy,in order to provide reference for predicting the prognosis of MP children. Methods Totally 110 MP children in Shiyan Maternal and Child Health Hospital were enrolled in the observation group and 110 healthy children were included in the control group from February 2015 to February 2017. The observation group was given conventional comprehensive treatment. The levels of serum SAA,HC-gp39,IgA,IgG and IgM of two groups at admission,before and after treatment in observation group were compared. After treatment,the observation group was divided into effective group and invalid group according to the treatment efficacy results. Pearson correlation analysis was used to determine the correlation between serum SSA and HC-gp39 levels before treatment and the efficacy. Results The serum SSA,HC-gp39,and IgG levels at admission in the observation group were significantly higher than those in control group(P<0.05). After treatment,the serum levels of SSA,HC-gp39,and IgG in observation group were lower than those before treatment(P<0.05). The serum SSA,HC-gp39 levels were positively correlated with IgG(r=0.524,0.394,P<0.05) and negatively related to efficacy(r=-0.613,-0.502,P<0.05). Conclusion The levels of serum SSA and HC-gp39 in MP children are significantly higher than those in healthy children,and are positively correlated with IgG and negatively correlated with efficacy.