Objective To establish the early warning score of cerebral palsy in twist-movements infants based on detailed assessment of general movements the study of high-risk infants. Methods The high-risk children who established archives in the department of rehabilitation in Xuzhou Children's Hospital were selected as participants from January 2016 to January 2017.The general movements feature evaluation and refinement score were conducted at corrected age of 4-6 weeks.And 52 neurological exercises were tested for infants at corrected age of 4-8 weeks.At 12 months old (corrected age of 44-52 weeks), different developmental outcomes were determined according to the diagnostic criteria for cerebral palsy.According to the research of health statistics, the early warning score of twist movements detailed assessment was established. Results The detailed assessment scores of twist-movements were significantly different among normal group, poor repertoire group, and synchronous exercise group (F=208.186,P<0.001).It was also positively correlated with 52 items scores(r=0.968, P<0.001).The normal motor development group ("green area") ranged from 27 to 42 points, which was equivalent to more than 27 points.The range of mild abnormalities ("yellow area") ranged from 18 to 26 points.The range of severe abnormalities ("red area") ranged from 5 to 17 points, which was equivalent to 17 points or less.The cerebral palsy warning score of this data showed that the predictive validity was 92.11%, the sensitivity was 100%, the specificity was 90.00%, the positive predictive value was 72.73%, the negative predictive value was 100%, the false positive rate was 10%, and the false negative rate was 0. Conclusion The establishment of warning score on cerebral palsy has higher sensitivity and specificity, lower false positive/negative rates, which can be used by medical personnel in clinical practice.