Objective To investigate the influencing factors and effect of comprehensive intervention on developmental language delay in children. Methods A total of 61 children with developmental language delay aged 18-35 months were chosen and 55 normal children were matched by gender and age from September 2017 to March 2018.Children with developmental language delay were divided into two groups, with 31 children in comprehensive intervention group and 30 children in family language intervention group.Early Language Development Process Scale and Family Environment Questionnaire were used to access children′s language development level and home environmental factors. Results Parents′ child-bearing age, home address, feeding type, parents′ education level, time spending on electronic products each day were found relative with children′s language development problems(P<0.05).Logistic regression analysis showed that more-time to interact with children(2~4 h/d OR=0.542, 95%CI:0.352~0.866;≥4 h/d OR=0.211,95%CI:0.105~0.402), more-educated mothers(high school OR=0.685, 95%CI: 0.495~0.947; college and more-educated experience OR=0.468, 95%CI:0.157~0.785)and breast feeding(OR=0.702, 95%CI:0.538-0.886)were protective factors for developmental language delay, while spending on electronic products≥1 h/d(OR=3.582,95%CI:2.314-5.761)was a risk factor.There was significant statistical difference between the comprehensive intervention group and the control group after 3 months of intervention(P＜0.05). Conclusion Children′s language development is closely related to family language environment, and comprehensive intervention proves to be a better method to treat language delayin children.