Predictive value of cord blood markers in neonatal early-onset sepsis

Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (2) : 171-174.

PDF(526 KB)
PDF(526 KB)
Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (2) : 171-174. DOI: 10.11852/zgetbjzz2018-0998

Predictive value of cord blood markers in neonatal early-onset sepsis

Author information +
History +

Abstract

Neonatal mortality has become one of the important indicators for measuring the level of health development in a country.Because of the low immunity, newborns are prone to developing various infectious diseases after birth, and the infection is difficult to control.Early detection, as well as timely and rational use of antibiotics to treat infections have become an urgent problem to be solved.This review describes the predictive value of C-reactive protein, procalcitonin, interleukin 6, and hepcidin in cord blood for early-onset sepsis in neonates, and illustrates the action and mechanism of various factors, as well as the interaction of maternity, placenta and fetus.

Key words

neonates / early-onset sepsis / hepcidin / C-reactive protein / procalcitonin / interleukin 6

Cite this article

Download Citations
Predictive value of cord blood markers in neonatal early-onset sepsis[J]. Chinese Journal of Child Health Care. 2019, 27(2): 171-174 https://doi.org/10.11852/zgetbjzz2018-0998

References

[1] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2015:340.
[2] Stoll BJ, Hansen NI, Adams-Chapman I, et al.Neurodevelopmental and growth impairmentamong extremely low-birth-weight infants with neonatal infection[J].JAMA,2004,292(19):2357-2365.
[3] Cotton CM.Adverse consequences of neonatal antibiotic exposure[J].Curr Opin Pediatr,2016,28(2):141-149.
[4] Chakraborty C, Agrawal A.Computational analysis of C-reactive protein for assessment of molecular dynamics and interaction properties[J].Cell Biochem Biophys,2013,67(2):645-656.
[5] Black S, Kushner I, Samols D.C-reactive protein[J].J Biol Chem,2004,279(47):48487-48490.
[6] Pepys MB.C-reactive protein fifty years on[J].Lancet,1981,1(8221):653-657.
[7] Cicarelli LM, Perroni AG, Zugaib M, et al.Maternal and cord blood levels of serum amyloid A, C-reactive protein, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 duringand after delivery[J].Mediators Inflamm,2005,2005(2):96-100.
[8] Mithal LB, Palac HL, Yogev R, et al.Cord blood acute phase reactants predict early onset neonatal sepsis in preterm infants[J].PLoS One,2017,12(1):e0168677.
[9] Ng PC, Lee CH, Fok TF, et al.Central nervous system candidiasis in preterm infants:limited value of biochemical markers for diagnosis[J].J Paediatr Child Health,2000,36(5):509-510.
[10] Dllner H, Vatten L, Halgunset J, et al.Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors[J].BJOG,2002,109(5):534-539.
[11] Hofer N, Zacharias E, Muller W, et al.An update on the use of C-reactive protein in early-onset neonatal sepsis:current insights and new tasks[J].Neonatology,2012,102(1):25-36.
[12] Maruna P, Nedelnikova K, Gurlich R.Physiology and genetics of procalcitonin[J].Physiol Res,2000,49(Suppl 1):57-61.
[13] Assumma M, Signore F, Pacifico L, et al.Serum procalcitonin concentrations in term delivering mothers and their healthy offspring:a longitudinal study[J].Clin Chem,2000,46(10):1583-1587.
[14] Turner D, Hammerman C, Rudensky B, et al.Procalcitonin in preterm infants during the first few days of life:introducing an age related nomogram[J].Arch Dis Child Fetal Neonatal Ed,2006,91(4):F283-F286.
[15] Chiesa C, Panero A, Rossi N, et al.Reliability of procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates[J].Clin Infect Dis,1998,26(3):664-672.
[16] Joram N, Muller JB, Denizot S, et al.Umbilical cord blood procalcitonin level in early neonatal infections:a 4-year university hospital cohort study[J].Eur J Clin Microbiol Infect Dis,2011,30(8):1005-1013.
[17] Joram N, Boscher C, Denizot S, et al.Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection[J].Arch Dis Child Fetal Neonatal Ed,2006,91(1):F65-F66.
[18] Duncombe G, Veldhuizen RA, Gratton RJ, et al.IL-6 and TNF alpha across the umbilical circulation in term pregnancies:relationship with labour events[J].Early Hum Dev,2010,86(2):113-117.
[19] Steinborn A, Sohn C, Sayehli C, et al.Spontaneous labour at term is associated with fetal monocyte activation[J].Clin Exp Immunol,1999,117(1):147-152.
[20] Steinberger E, Hofer N, Resch B.Cord blood procalcitonin and interleukin-6 are highly sensitive and specific in the prediction of early-onset sepsis in preterm infants[J].Scand J Clin Lab Invest,2014,74(5):432-436.
[21] Cernada M, Badia N, Modesto V, et al.Cord blood interleukin-6 as a predictor of early-onset neonatal sepsis[J].Acta Paediatr,2012,101(5):e203-e207.
[22] Cobo T, Kacerovsky M, Andrys C, et al.Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes[J].PLoS One,2013,8(7):e69341.
[23] Wirbelauer J,Seidenspinner S,Thomas W,et al.Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants≤ 32 weeks of gestion[J].Eur J Obstet Gyn R B,2011,155(1):31-35.
[24] Peyssonnaux C, Zinkernagel AS, Datta V, et al.TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens[J].Blood,2006,107(9):3727-3732.
[25] Rehu M, Punnonen K, Ostland V, et al.Maternal serum hepcidin is low at term and independent of cord blood iron status[J].Eur J Haematol,2010,85(4):345-352.
[26] Cizmeci MN, Kara S, Kanburoglu MK, et al.Detection of cord blood hepcidin levels as a biomarker for early-onset neonatal sepsis[J].Med Hypotheses,2014,82(3):310-312.
[27] Pedersen BK, Febbraio MA.Muscle as an endocrine organ:focus on muscle-derived interleukin-6[J].Physiol Rev,2008,88(4):1379-1406.
[28] Pedersen BK.Muscle as a secretory organ[J].Compr Physiol,2013,3(3):1337-1362.
[29] El-Mashad AR, Elmahdy H, El-Dib M, et al.Can melatonin be used as a marker for neonatal sepsis[J].J Matern Fetal Neonatal Med,2016,29(17):2870-2873.
[30] Walker VP, Zhang X, Rastegar I, et al.Cord blood vitamin D status impacts innate immune responses[J].J Clin Endocrinol Metab,2011,96(6):1835-1843.
PDF(526 KB)

Accesses

Citation

Detail

Sections
Recommended

/