Clinical efficacy of budesonide combined with caffeine citrate for preventing bronchopulmonary dysplasia in preterm infants

CHEN Meng-Meng; WEN Xiao-hong; HUANG Jin-hua; SUN Ya-wei

doi:10.11852/zgetbjzz2018-0947

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (10) : 1124-1127. DOI: 10.11852/zgetbjzz2018-0947

Clinical efficacy of budesonide combined with caffeine citrate for preventing bronchopulmonary dysplasia in preterm infants

CHEN Meng-Meng, WEN Xiao-hong, HUANG Jin-hua, SUN Ya-wei

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Abstract

Objective To explore the clinical efficacy of early inhaled budesonide combined with caffeine citrate for preventing bronchopulmonary dysplasia(BPD) in very low birth weight(VLBW) infants,in order to provide evidence for the prevention and treatment of BPD. Methods A total of 60 VLBW infants with gestational age under 32 weeks and weight under 1 500 g in Binhu Hospital of Southern District,the First Hospital of Hefei City were enrolled in this study from October 2014 to October 2017,and were randomly assigned into budesonide combined with caffeine group(n=30) and caffeine group(n=30).Duration of ventilation,duration of oxygen supplementation,duration of hospitalization,mortality,incidence of BPD and common complications between the two groups were compared. Results Compared with the caffeine group,budesonide combined with caffeine group had a shorter duration of ventilation and oxygen supplementation(t=2.09,Z=-2.36,P <0.05).The incidence of BPD in budesonide combined with caffeine group was lower than that in caffeine group,but the difference was not statistically significant(P＞0.05).There were no significant differences on the duration of hospitalization and the incidence of other common complications between the two groups(P>0.05). Conclusion Early inhaled budesonide combined with caffeine citrate can effectively shorten the duration of ventilation and oxygen supplementation,and can reduce the incidence of BPD to some extent.

Key words

budesonide / caffeine citrate / bronchopulmonary dysplasia / very low birth weight infants

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CHEN Meng-Meng, WEN Xiao-hong, HUANG Jin-hua, SUN Ya-wei. Clinical efficacy of budesonide combined with caffeine citrate for preventing bronchopulmonary dysplasia in preterm infants[J]. Chinese Journal of Child Health Care. 2019, 27(10): 1124-1127 https://doi.org/10.11852/zgetbjzz2018-0947

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