Objective To detect serum levels of 25-(OH)D,calcium (Ca),phosphorus (P) and parathyroid hormone (PTH) in children with mild rotavirus enteritis and benign convulsions,in order to provide reference for clinical vitamin D supplementation. Methods A total of 58 cases of children aged 6 months to 2 years,who were with mild rotavirus enteritis and benign convulsions in Jiangmen Central Hospital from October to March in the following year from 2015 to 2018,were selected into case group.And 62 healthy children at the same time were selected as control group.Serum 25-(OH) D,calcium,phosphorus,PTH level and fecal rotavirus were tested in the two groups. Results 1)In all subjects,most serum 25-(OH)D concentrations were insufficient or deficient,only few were sufficient.2) Serum calcium and 25-(OH)D concentration in case group was significantly lower than those in control group (P<0.05),while the differences on serum P and PTH concentrations between the two groups were not significant (P>0.05).3) Serum 25-(OH)D concentration was negatively correlated with PTH concentration in case group and control group (r=-0.324,-0.264,P<0.05). Conclusion The serum level of 25-(OH) D in children in Jiangmen city is generally insufficient or deficient.And the low levels of serum Ca and 25-(OH)D may be the potentially risk factors for mild rotavirus enteritis and benign convulsions.The level of serum 25-(OH)D in the case group was lower than that in the control group.
Key words
mild rotavirus enteritis /
benign convulsions /
children /
vitamin D /
calcium /
phosphorus /
parathyroid hormone
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References
[1] Verrotti A,Tocco AM,Coppola GG,et al.A febrile benign convulsions with mild gastroenteritis: a new entity?[J].Acta Neurol Scand,2009,120:73-79.
[2] Kang B,Kwon YS.Benign convulsion with mild astroenteritis[J].Korean J Pediatr,2014.57(7):304-309.
[3] Holick MF.Vitamin D deficiency[J].N Engl J Med,2007,357(3):266-281.
[4] Fuleihan G,Bouillon R,Clarke B,et al.Serum 25-hydroxyvitamin D levels: variability,knowledgegaps,and the concept of a desirable range[J].Bone Miner Res,2015,30(7):1119-1133.
[5] Bucak IH,Qzturk AB,Alims H,et al.Is there a relationship between low vitamin D and rotaviral diarrhea?[J].Pediatr Int,2016,58(4):270-273.
[6] 中华医学会儿科学分会儿童保健学组,《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[7] 符传博,丹利,唐家翔,等.1960-2013年华南地区霾污染大的时空变化及其与关键气候因子的关系[J].中国环境科学,2016,35(5):1313-1322.
[8] Carole BA,Raphael EC,Christine BF,et al.Sunlight and vitamin D:necessary for public health[J].J Am Coll Nutr,2015,34(4): 359-365.
[9] 秦振英,梁冠禹,胡幼芳,等.儿童户外活动及体质指数与VitD营养状况的关系研究[J].中国儿童保健杂志,2017,25(4):334-337.
[10] Yeom JS,Kim YS,Park JS,et al.Role of Ca2+ homeostasis disruption in rotavirus-associated seizures[J].Child Neuro,2014;29(3):331-335.
[11] Tsiaras WG,Weinstock MA.Factors influencing vitamin D status[J].Acta Derm Venereol,2011,91(2):115-124.
[12] Haddow JE,Neveux LM,Palomaki GE,et al.The relationship between PTH and 25-hydroxy vitamin D early inpregnancy[J].Clin Endocrinol,2011,75(3):309-314.
[13] Pekkinen M,Saarnio E,Viljakainen HT,et al.Vitamin D binding protein genotype Is associated with serum 25-hydroxy vitamin D and PTH concentrations,as well as bone health in children and adolescents in Finland[J].PLoS One,2014,9(1): e87292.
[14] Houghton LA,Szymlek-Gay EA,GrayAR,et al.Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children[J].Am J Clin Nutr,2010,92(1):69-76.
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