Objective To research the clinical effect of family intervention in children with autism spectrum disorder(ASD),in order to provide evidence for its clinical application. Methods A total of 76 cases of ASD children were selected as participants in Xiangyang Maternal and Child Health Care Hospital from April 2017 to April 2018.And the participants were divided into the observation group (n=43) and control group (n=33) according to whether receiving training at home or not.Children of the control group were not intervened by their parents at home,and were only trained for half a day in the morning in hospital.The observation group were trained by their parents at home anytime and anywhere additionally.Chidren were assessed by the ASD Treatment Evaluation Scale (ATEC) and the ASD Behavior Checklist (ABC) before and after treatment,and were assessed by the match of their facial expression cards at the same time. Results Before treatment,there were no significant differences on the score ATEC and ABC scales between the two groups (t=0.21,0.24,P>0.05) ).After treatment,the scores of ATEC and ABC in observation group were significantly lower than those in control group(t=8.55,9.51) and those before treatment(t=7.02,10.97),and the differences were significant(P<0.05).In addition,there was statistically significant difference on the matching indexes of facial expression cards such as sadness,joy,anger and fear between the two groups (t=12.14,8.16,8.34,4.31,P<0.05). Conclusions Comprehensive interventions in hospitals and home can result in better efficacy,so it is worth popularizing and being applied in rehabilitation treatment.