Progress on the mechanism of intrauterine growth restriction affecting cognitive development

LIU Wen-jing,YUAN Zhao-hong

Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (3) : 281-284.

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (3) : 281-284. DOI: 10.11852/zgetbjzz2018-0672

Progress on the mechanism of intrauterine growth restriction affecting cognitive development

  • LIU Wen-jing,YUAN Zhao-hong
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Abstract

Intrauterine growth restriction(IUGR) refers to the fact that fetal development in the uterus does not reach its growth potential due to genetic or environmental factors. IUGR is not only associated with peripartum asphyxia,hypothermia,hypoglycemia and other diseases,but also can affect the long-term development of the nervous system,resulting in cognitive developmental disorders,behavioral problems. This article reviews the mechanism that IUGR may impair cognitive development in terms of fetal circulatory redistribution,brain volume and structure,brain metabolism,and epigenetic inheritance,in order to provide basis for revealing and intervening cognitive impairment caused by IUGR.

Key words

intrauterine growth restriction / cognition / mechanism

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LIU Wen-jing,YUAN Zhao-hong. Progress on the mechanism of intrauterine growth restriction affecting cognitive development[J]. Chinese Journal of Child Health Care. 2019, 27(3): 281-284 https://doi.org/10.11852/zgetbjzz2018-0672

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