Research progress on zebrafish models of autism spectrum disorder

WANG Yi; LIU Chun-xue; XU Xiu

doi:10.11852/zgetbjzz2018-0529

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (1) : 46-50. DOI: 10.11852/zgetbjzz2018-0529

Research progress on zebrafish models of autism spectrum disorder

WANG Yi, LIU Chun-xue, XU Xiu

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Abstract

Autism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental conditions,characterized by social deficits and the presence of repetitive stereotypic behaviors and restricted interests. The biological mechanisms of ASD have not been completely identified. As a fundamental research tool,animal model is comprehensively applied to study genetic basis,neuropathological mechanisms as well as pharmaceutical researches. Zebrafish models have been popularized as typical ASD models based on the advantages of the external fertilization,high fecundity,rapid development,optical transparence of embryos and larvae which allow real-time imaging of developing pathologies,drug screening on a large scale economically. This review thus aims to summarize the achievements of zebrafish for modeling ASD.

Key words

autism spectrum disorder / zebrafish / genetics / behavior / drug evaluation

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WANG Yi, LIU Chun-xue, XU Xiu. Research progress on zebrafish models of autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2019, 27(1): 46-50 https://doi.org/10.11852/zgetbjzz2018-0529

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