Clinical characteristics and the concordance rates of 58 pairs of ascertained autism spectrum disorder

DENG Wen-lin; XING Yi-pei; WANG Fang; YOU Cong; CHEN Bi-yuan; LIANG Ya-yong; DENG Hong-zhu; ZOU Xiao-bin

doi:10.11852/zgetbjzz2018-0126

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (1) : 23-25. DOI: 10.11852/zgetbjzz2018-0126

Clinical characteristics and the concordance rates of 58 pairs of ascertained autism spectrum disorder

DENG Wen-lin¹, XING Yi-pei², WANG Fang², YOU Cong², CHEN Bi-yuan², LIANG Ya-yong², DENG Hong-zhu², ZOU Xiao-bin²

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Abstract

Objective To analyze the clinical characteristics and the concordance rates of 58 pairs of ascertained autism spectrum disorder(ASD) and to discuss their genetic patterns and risk factors. Methods ASD twins were collected from Children's Development Behavior Center, the Third Affiliated Hospital of Sun Yat-sen University in 1999-2015. Totally 58 pairs of ASD twins in the follow-up program were analyzed,and at least 1 twin had been diagnosed with an ASD in each pair. R software was used to analyze data. Results The birth weight of twins was lower,the gestational age was lower,the perinatal period had more risk factors. The concordance rates of monozygotic twins was 73.68%,while 12.82% for dizygotic twins,and the difference was statistically significant(χ²=18.81,P＜0.01). Conclusion ASD monozygotic twins have high concordance rates,indicating that the genetic factors are one of the important etiology.

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autism spectrum disorder / genetics / twins / concordance rate

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DENG Wen-lin, XING Yi-pei, WANG Fang, YOU Cong, CHEN Bi-yuan, LIANG Ya-yong, DENG Hong-zhu, ZOU Xiao-bin. Clinical characteristics and the concordance rates of 58 pairs of ascertained autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2019, 27(1): 23-25 https://doi.org/10.11852/zgetbjzz2018-0126

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