Objective To analyze the correlation between endothelial nitric oxide synthase (eNOS) polymorphism (AGT M235T, ACE I/D, eNOS G894T, eNOS T-786C) and encephalopathy of prematurity, in order to provide reference for assessing the patients′ condition comprehensively. Methods Preterm infants with gestational age under 34 weeks in neonatal intensive care unit (NICU) of Xinxiang Central Hospital were enrolled in this study from June 2014 to September 2017. Head ultrasound and magnetic resonance imaging of the patients were conducted, and gene polymorphisms were tested. Clinical data of the participants were retrospectively collected. The correlation among AGT M235T, ACE I/D, eNOS G894T, eNOS T-786C and encephalopathy of prematurity was analyzed. Result It was found that eNOS T-786C TC+CC polymorphism was an independent risk factors for encephalopathy of prematurity (OR＝3.206,95%CI:1.850~7.652). Conclusions There is genetic susceptibility in encephalopathy of prematurity. And gene polymorphism test is helpful to assess the prognosis of preterm infants.
Key words
polymorphism /
encephalopathy of prematurity /
endothelial nitric oxide synthase /
magnetic resonance imaging
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