Objective To investigate the value of serum cystatin C (Cys C) in the renal function evaluation of neonatal asphyxia,and to provide evidence for clinical diagnosis and treatment. Methods A total of 79 newborns with neonatal asphyxia were collected in a Grade Ⅲ Level A hospital in Shaanxi,including 37 males and 42 females.According to the Apgar score of neonatal asphyxia,55 cases were divided into mild asphyxia group and 24 cases as severe asphyxia group.Another 50 healthy newborns (27 male and 23 female) were selected as control group.The serum levels of Cys C,creatinine (Cr),and blood urea nitrogen (BUN) were compared among three groups. Results The level of serum Cys C in mild asphyxia group was significantly higher than that in control group (P<0.01),but there was no significant difference on the levels of BUN and Cr between mild asphyxia group and control group (both P>0.05);Compared with the mild asphyxia group,the levels of BUN,Cr and Cys C in severe asphyxia group were significantly higher and the differences were statistically significant (all P<0.05).The abnormal rates of BUN,Cr and Cys C in mild asphyxia group were 29.0%,25.5% and 21.8% respectively,among which there was no statistical difference.However,the abnormal rate of Cys C (87.5%) was significantly higher than that of BUN and Cr (41.7% and 33.3%,respectively) in severe asphyxia group (χ2=6.97,P<0.01).Serum Cys C was positively correlated with the level of BUN and Cr (r=0.84,0.88,both P<0.05). Conclusions Serum Cys C could be used as a sensitive index for evaluation of kidney damage after neonatal asphyxia,and its diagnostic value for early renal damage would be higher than that of serum BUN or Cr.The results might be of great significance in monitoring renal function for asphyxia newborns,evaluating the disease progress and analyzing the prognosis in clinical practice.
Key words
neonatal asphyxia /
cystatin C /
renal function impairment
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