Research progress on cardiovascular disease markers in children with growth hormone deficiency

WANG Pan-pan; LI Yan-ying; BAN Bo

doi:10.11852/zgetbjzz2017-25-12-15

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (12) : 1239-1242. DOI: 10.11852/zgetbjzz2017-25-12-15

Research progress on cardiovascular disease markers in children with growth hormone deficiency

WANG Pan-pan¹, LI Yan-ying², BAN Bo²

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Abstract

Growth hormone deficiency (GHD) refers to the growth and developmental disorders caused by the lack of growth hormone (GH) released by the anterior lobe synthesis and secretion,or due to abnormal GH molecular structure.Treatment of recombinant human growth hormone (rhGH) in children with GHD not only promotes linear growth,but also affects related cardiovascular disease (CVD) markers such as lipid,inflammatory mediators,fats cytokines,oxidative stress substances,coagulation-fibrinolytic system and other biochemical indicators,body composition and epicardial adipose tissue thickness,carotid intima media thickness and other ultrasonic indicators,all of these factors are involved in atherosclerosis(AS) process and can lead to the occurrence of CVD.In recent years,studies on the changes of related CVD markers before and after rhGH treatment in children with GHD have also been of great concern in the long-term safety of rhGH.

Key words

growth hormone deficiency / growth hormone / cardiovascular disease markers / cardiovascular disease

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WANG Pan-pan, LI Yan-ying, BAN Bo. Research progress on cardiovascular disease markers in children with growth hormone deficiency[J]. Chinese Journal of Child Health Care. 2017, 25(12): 1239-1242 https://doi.org/10.11852/zgetbjzz2017-25-12-15

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