Analysis on association between FADS1,FADS2 genes polymorphisms and ASD of Han nationality children in China

KANG Jing; ZOU Ming-yang; MA Yong-juan; SONG Xiao-huan; SUN Cai-hong; HAO Yan-qiu; XIA Wei; WU Li-jie

doi:10.11852/zgetbjzz2017-25-12-03

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (12) : 1196-1199. DOI: 10.11852/zgetbjzz2017-25-12-03

Analysis on association between FADS1,FADS2 genes polymorphisms and ASD of Han nationality children in China

KANG Jing¹, ZOU Ming-yang¹, MA Yong-juan¹, SONG Xiao-huan², SUN Cai-hong¹, HAO Yan-qiu³, XIA Wei¹, WU Li-jie¹

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Abstract

Objective To analyze whether single nucleotide polymorphisms(SNPs) in FADS1 and FADS2 genes involved in polyunsaturated fatty acids metabolism are related to the risk of autism spectrum disorder (ASD) among Chinese population. Methods A total of 243 subjects with ASD and 243 control subjects were enrolled in this case-control study.Genomic DNA was extracted from peripheral whole blood samples.The human genome database and the Haploview 4.2 software were used to select tag SNPs.All tag SNPs genotyping were set by using the Sequenom Mass ARRAY.Associations between the tag SNPs and ASD were analyzed by logistic regression analysis. Results The allele and genotype frequencies at rs526126 in FADS2 showed significant differences between autistic children and control group[rs526126 G allele OR=0.54(0.41～0.72),P<0.001,G/G genotype OR=0.05(0.02～0.18),P<0.001]. Conclusion This study provides supportive evidence on association of the polymorphisms in FADS2 gene with ASD risk in Chinese Han nationality population.

Key words

autism / FADS1 / FADS2 / polyunsaturated fatty acids / single nucleotide polymorphisms

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KANG Jing, ZOU Ming-yang, MA Yong-juan, SONG Xiao-huan, SUN Cai-hong, HAO Yan-qiu, XIA Wei, WU Li-jie. Analysis on association between FADS1,FADS2 genes polymorphisms and ASD of Han nationality children in China[J]. Chinese Journal of Child Health Care. 2017, 25(12): 1196-1199 https://doi.org/10.11852/zgetbjzz2017-25-12-03

References

[1] King BH,Navot N,Bernier R,et al.Update on diagnostic classification in autism[J].Curr Opin Psychiatry,2014,27(2):105-109.
[2] Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators.Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network,14 sites,united states,2008[J].MMWR Surveill Summ,2012,61(3):1-19.
[3] Autism and Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators.Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network,11 sites,united states,2010[J].MMWR Surveill Summ,2014,63(2):1-21.
[4] Jory J.Abnormal fatty acids in Canadian children with autism[J].Nutrition,2015,32(4):474-477.
[5] 武丽杰.多不饱和脂肪酸与孤独症发病关联的研究进展[J].中国儿童保健杂志,2013,21(6):565-566.
[6] Guha M.Diagnostic and Statistical Manual of Mental Disorders:DSM-5 (5th edition)[J].Reference Reviews,2014,28(3):36-37.
[7] 庞伟,康倩倩,郭岚敏,等.孤独症儿童血浆多不饱和脂肪酸水平研究[J].中国康复理论与实践,2011,17(8):742-744.
[8] Drumond A,Madeira N,Fonseca R.Endocannabinoid signaling and memory dynamics:a synaptic perspective[J].Neurobiol Learn Mem,2017,138:62-77.
[9] Joffre C,Nadjar A,Lebbadi M,et al.n-3 LCPUFA improves cognition:the young,the old and the sick[J].Prostaglandins Leukot Essent Fatty Acids,2014,91(1-2):1-20.
[10] McNamara RK,Strawn JR.Role of long-chain Omega-3 fatty acids in psychiatric practice[J].Pharma Nutrition,2013,1(2):41-49. [11] Bousquet M,Gue K,Emond V,et al.Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease[J].J Lipid Res,2011,52(2):263-271.
[12] Schuchardt JP,Kobe T,Witte V,et al.Genetic variants of the FADS gene cluster are associated with erythrocyte membrane LC PUFA levels in patients with mild cognitive impairment[J].J Nutr Health Aging,2016,20(6):611-620.
[13] 孙蒙,王涵,王茂清,等.利用UPLC/Q-TOF MSMS对孤独症患儿血清的代谢组学分析[J].中国儿童保健杂志,2013,21(1):6-9.
[14] Gang Z,Gao J,Shuang L,et al.Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model[J].Int J Dev Neurosci,2015,44:14-21.
[15] Roke K,Ralston JC,Abdelmagid S,et al.Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults[J].Prostaglandins Leukot Essent Fatty Acids,2013,89(4):257-263.
[16] Morales E,Bustamante M,Gonzalez JR,et al.Genetic variants of the FADS gene cluster and ELOVL gene family,colostrums LC-PUFA levels,breastfeeding,and child cognition[J].PLoS One,2011,6(2):e17181.
[17] Tosi F,Sartori F,Guarini P,et al.Delta-5 and delta-6 desaturases:crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease[J].Adv Exp Med Biol,2014,824:61-81.
[18] Young AMH,Chakrabarti B,Roberts D,et al.From molecules to neural morphology:understanding neuroinflammation in autism spectrum condition[J].Mol Autism,2016,7(1):1-8.