Objective To investigate the relationship between chorioamnionitis or funisitis and diseases in preterm infants with gestational age less than 34 weeks. Method A total of 151 premature infants with gestational ages less than 34 weeks were enrolled.According to placental pathology,subjects were divided into CA(-)FV(-)group,CA(+)FV(-)group,and CA(+)FV(+)group.Incidence of diseases and the infection parameters among three groups were compared. Result The incidence of diseases increased with the progress of inflammation,and the incidence rates of pneumonia,respiratory distress syndreme (RDS),intracranial hemorrhage,and necrotizing enterocolitis (NEC) in three groups were significantly different (P<0.05).Prenatal fever,white blood cell count(WBC) of prenatal maternal infection,C reactive protein (CRP) and neonatal calcitonin peptide(PCT)were significantly different (P<0.05).With the increasing of the infection index,tissue type chorioamnionitis and funisitis increased gradually,while the difference of the prenatal N% and infection index of preterm infants was not significant (P>0.05). Conclusion Exposure to chorioamnionitis or funisitis will lead to higher incidence of organ damage in preterm infants of gestational age less than 34 weeks.Also,the incidence rates of pneumonia,RDS,intracranial hemorrhage,NEC are closely correlated with chorioamnionitis or funisitis.The levels of WBC,C reactive protein(CRP) and neonatal calcitonin peptide(PCT)could be an indicator to predict the occurrence of chorioamnionitis or funisitis in preterm infants.
Key words
chorioamnionitis /
funisitis /
premature /
diseases
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References
[1] 李娟,王庆红,吴红敏,等.2005年中国城市产科新生儿出生状况调查[J].中国当代儿科杂志,2012,14(1):7-10.
[2] Yoon BH,Romero R,Park JS,et al.The relationship among inflammatory lesions of the umbilical cord (funisitis),umbilical cord plasma interleukin 6 concentration,amniotic fluid infection,and neonatal sepsis[J].Am J Obstet Gynecol,2000;183(5):1124.
[3] 朱燕,陈超.出生早产儿流行病学特征的前瞻性多中心调查[D].上海:复旦大学,2012.
[4] Kim CJ,Romero R,Chaemsaithong P,et al.Acute chorioamnionitis and funisitis:definition,pathologic feathures,and clinica significace[J].Am J Obstet Gynecol,2015,213(4Suppl):s29-s52.
[5] Redline RW,Faye-Petersen O,Heller D,et al.Amniotic infection syndrome:nosology and reproducibility of placental reaction patterns[J].Pediatr Dev Pathol,2003,6(5):435-48.
[6] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].北京:人民卫生出版社,2010.
[7] 刘晓巍,范玲,张为远等.新生儿宫内感染 43 例的相关因素分析[J].中华临床医师杂志:电子版,2011,5(5):3027-3030.
[8] 单若冰.宫内感染与新生儿肺疾病[J].中国小儿急救医学,2016,23(5):304-311.
[9] 史学凯,农绍汉,高平明,等,胎盘组织炎症对早产儿脑室内出血发病风险的影响[J],中国新生儿科杂志,2010,25(3):139-142.
[10] Liu Z,Tang Z,Li J,et a1.Effects of placental inflammation on neonatal outcome in preterm infants[J].Pediatr Neonatol,2014,55(1):35-40.
[11] Sase M,Miwa I,Sumie M,et al.Ontogeny of gastric emptying patterns in the human fetus[J].J Matern Fetal Neonatal Med,2005,17(3):213-217.
[12] Perrone G,Anceschi MM,Capri O,et al.Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of embranes[J].Gyneeol Obstet Inves,2012,74(2):95-99.
[13] 王月英,申丽红,韩专叶,等.血清C反应蛋白、白介素-6在绒毛膜羊膜炎诊断中的价值分析[J].临床合理用药,2015,8(12A):167-168.
[14] 彭凤梅.Hs-CRP、CRP预测胎膜早破早产儿宫内感染的价值及菌群分布情况研究[J].中国妇幼保健,2015,30(24):4149-4152.
[15] 高芳,单若冰.C-反应蛋白检测在新生儿感染性疾病中的应用价值[J].吉林医学,2010,31(15):2188.
[16] 袁仕伟,张跃军,郑卫东,等.降钙素原、C-反应蛋白及IL-6、在早产胎膜早破新生儿败血症中的诊断价值[J].中国医药导报,2012,9(15):114-118.
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