Objective To investigate the effect of intrahepatic cholestasis of pregnancy(ICP) on pregnancy outcomes and neonates. Methods A total of 173 pregnant women who were diagnosed with ICP and delivered in gynecology department of Guizhou Provincial People's Hospital were classified as ICP group,and 180 healthy pregnant women were classified as control group from May 2013 to April 2017.Related indexs including maternal age,gravidity,parity,delivery mode,pregnancy outcomes and the neonatal laboratory indexes and diseases were collected and compared between the two groups. Results There was no significant difference on maternal age and times of pregnancy between the two groups,but the times of gravidity and the proportions of cesarean section in ICP group were significantly higher than those in control group (P<0.05);The proportions of low birth weight infants,meconium stained amniotic fluid,and asphyxia in ICP group were significantly higher than those in control group (P<0.05);The levels of TC,ALP and TBA in ICP group were significantly higher than those in control group (P<0.05). Conclusion ICP can cause neonatal birth and postpartum abnormalities,such as low birth weight infants,meconium stained amniotic fluid,asphyxia,and neonatal ALP,TBA abnormalities.
Key words
intrahepatic cholestasis of pregnancy /
pregnancy outcome /
neonatal diseases
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References
[1] 陆剑锋,张岩.妊娠期肝内胆汁淤积症与围产儿预后的临床研究[J].中国妇幼保健,2015,30(35):6193-6195.
[2] 李蕾,赵新颜,欧晓娟,等.妊娠期肝内胆汁淤积症的临床分析[J].中华肝脏病杂志,2013,21(4):295-299.
[3] 龚源.妊娠期肝内胆汁淤积症胆汁酸、肝酶指标与围产儿预后的关系[J].检验临床与医学,2016,13(10):1420-1422.
[4] 李彩荣,陈玲.600 例妊娠期肝内胆汁淤积症围产结局分析及围产期胎儿监护的探讨[J].中国妇幼保健,2015,30(18):6210-6212.
[5] Hardikar W,Kansal S,Oude Elferink RP,et al.Intrahepatic cholestasis of pregnancy:when should you look further[J].World J Gastroenterol,2015,15(9):1126-1129.
[6] Jin WY,Lin SL,Hou RL,et al.Associations between maternal lipid profile and pregnancy complications and perinatal outcomes:a population-based study from China[J].BMC Pregnancy Childbirth,2016,16(1):60-69.
[7] DuQ,PanY,ZhangY,etal.Plancentalgene-expression pcrofils of intrahepatic cholestasis of pregnancy reveal invoivement of multiple molecular pathways inblood vessel formation and inflammation[J].BMC Med Genomics,2014,7:42-52.
[8] Floreani A,Caroli D,Lazzari R,et al.Intrahepatic cholestasis of pregnancy:new insights into its pathogenesis[J].J Matern Fetal Neonatal Med,2013,26:1410-1415.
[9] 张群锋,黄余良,等.瘦素在妊娠期肝内胆汁淤积症患者血清胎盘组织中的表达及意义[J].广东医学,2013,34(18):2838-2840.
[10] 程玲媛.妊娠期肝内胆汁淤积症患者的临床特点及胎盘病理学观察[J].中国初级卫生保健,2016,30(4):35-36.
[11] Sasaki M,Kakuda Y,Miyakoshi M,etal,Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis[J].J Clin Pathol,2014,67( 6):470-476.
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