Research progress on growth regulation of cartilage growth plate

WANG Pan-pan; SHAO Qian; BAN Bo

doi:10.11852/zgetbjzz2017-25-11-14

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (11) : 1131-1133. DOI: 10.11852/zgetbjzz2017-25-11-14

Research progress on growth regulation of cartilage growth plate

WANG Pan-pan¹,SHAO Qian²,BAN Bo²

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Abstract

Cartilage growth plate (CGP) is mainly composed of chondrocytes and extracellular matrix (ECM).The proliferation,differentiation,hypertrophy of chondrocytes,and the formation of ECM,are the key to the development of bone and linear growth.Therefore,the factors related to CGP that regulation growth mainly include growth hormone-like insulin-like growth factor-1 (GH-IGF-1) axis,various hormones,paracrine factors and inflammatory cytokines acting on chondrocytes and collagen in cartilage ECM,non-collagen glycoprotein,proteoglycan and other ingredients.Previous studies mostly focused on the regulation of GH-IGF-1 axis growth,but other relevant factors on CGP beyond GH-IGF-1 axis that can control the growth receives more concern in recent years.

Key words

growth plate / chondrocytes / extracellular matrix / regulation / growth

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WANG Pan-pan,SHAO Qian,BAN Bo. Research progress on growth regulation of cartilage growth plate[J]. Chinese Journal of Child Health Care. 2017, 25(11): 1131-1133 https://doi.org/10.11852/zgetbjzz2017-25-11-14

References

[1] Blumer MJ,Longato S,Fritsch H.Structure formation and role of cartilage canals in the developing bone[J].Ann Anat,2008,190(4):305-315.
[2] Adams SL,Cohen AJ,Lassova L.Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation[J].Cell Physiol,2007,213(3):635-641.
[3] 陈龙,陈晓青.特发性矮身材儿童生长障碍与GH-IGF1轴关系的研究进展[J].临床合理用药杂志,2016,9(10):179-181.
[4] Rosenfeld RG,Belgorosky A,Camacho-Hubner C,et al.Defects in growth hormone receptor signaling[J].Trends Endocrinol Metab,2007,18(4):134-141.
[5] Borjesson AE,Lagerquist MK,Windahl SH,et al.The role of estrogen receptor alpha in the regulation of bone and growth plate cartilage[J].Cell Mol Life Sci,2013,70(21):4023-4037.
[6] Nilsson O,Weise M,Landman EB,et al.Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits[J].Endocrinology,2014,155(8):2892-2899.
[7] Quaynor SD,EWS Jr,Kim HG,et al.Delayed puberty and estrogen resistance in a woman with estrogen receptor alpha variant[J].N Engl J Med,2013,369(2):164-171.
[8] Mauras N,Ross JL,Gagliardi P,et al.Randomized trial of aromatase inhibitors,growth hormone,or combination in pubertal boys with idiopathic,short stature[J].Clin Endocrinol Metab,2016,101(12):4984-4993.
[9] 袁意,杨玉,黄慧,等.雌激素受体基因单核苷酸多态性与特发性矮小的相关性研究[J].重庆医学,2014,43(23):2980-2982.
[10] 杨玉,柯江维,杨利,等.雌激素受体α基因多态性与性早熟女童骨龄指数的关系[J].南昌大学学报:医学版,2011,51(6):34-37.
[11] 周建伟,徐启明,邹德威,等.软骨生长板的调控系统研究进展[J].军医进修学院学报,2012,33(2):198-201.
[12] Lui JC,Baron J.Effects of glucocorticoids on the growth plate[J].Endocr Dev,2011,20:187-193.
[13] Kant SG,Cervenkoval I,Balek L,et al.A novel variant of FGFR3 causes proportionate short stature[J].Eur J Endocrinol,2015,172(6):763-770.
[14] Lui JC,Nilsson O,Baron J.Recent research on the growth plate:Recent insights into the regulation of the growth plate[J].Mol Endocrinol,2014,53(1):1-9.
[15] Martensson KD,Chrysis,Savendahl L.Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones[J].Bone Miner Res,2004,19(11):1805-1812.
[16] Blumbach K.Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture[J].Matrix Biol,2008,27(4):306-318.
[17] 周伏圣.COL11A1基因启动子多态与汉族人身高的关联分析[J].安徽医科大学学报,2009,44(3):331-334.
[18] 李正兰.ISS患儿NPR3、COL11A2基因单核苷酸多态性的研究[D].苏州:苏州大学,2011.
[19] Van der Steen M,Pfundt R,Maas SJ,et al.ACAN gene mutations in short children born SGA and response to Growth Hormone treatment[J].J Clin Endocrinol Metab,2017,102(5):1458-1467.
[20] Gibson BG,Briggs MD.The aggrecanopathies:an evolving phenotypic spectrum of human genetic skeletal diseases[J].Orphanet J Rare Dis,2016,11(1):86-93.
[21] Nilsson O,Guo MH,Dunbar N.Short stature,accelerated bone maturation,and early growth cessation due to heterozygous aggrecan mutations[J].Clin Endocrinol Metab,2014,99(8):1510-1518.
[22] Kim JJ,Lee HI,Park T.Identification of 15 loci influencing height in a Korean population[J].Hum Genet,2010,55(1):27-31.
[23] Michigami T.Regulatory mechanisms for the development of growth plate cartilage[J].Cell Mol Life Sci,2013,70(22):4213-4221.
[24] Cain SA,Mcgovern A,Baldwin AK.Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions[J].PLoS One,2012,7(11).486-492.
[25] Brooke BS,Habashi JP,Judge JP.Angiotensin II blockade and aortic-root dilation in Marfan's syndrome[J].N Engl J Med,2008,358(26):2787-2795.