Objective To explore the efficacy of PDMS-2 Motor Activities Program supervised by parents on high-risk infants,and to provide the ideas for a new rehabilitation model of high-risk infants. Methods A total of 54 cases of high-risk infants treated in Zhengzhou central Hospital from January to June 2016 were divided into control group with 26 cases and treatment group with 28 cases.Children of two groups were both given exercise therapy.The treatment group were assessed by PDMS-2 and corresponding PDMS-2 motor activities program was set up according to the PDMS-2 result.Infants were guided by parents to perform the PDMS-2 motor activities program.Gross motor function measure 88 (GMFM88) was used to assess the gross motor before treatment and 3 months after treatment in two groups. Results After treatment the motor development of the two groups both progressed and the treatment group was better than the control group with significant difference(P＜0.01). Conclusion The PDMS-2 Motor Activities Program guided by parents for the high-risk infants family rehabilitation will help infants recover earlier.