Study on the effectiveness and safety of Levetiracetam in the treatment of epilepsy in infants under 2 years old

YE Gao-bo; DONG Jian-peng; LI Dan; LIU Yu; WANG Xue-ying; YANG Lin; HUANG Shao-ping

doi:10.11852/zgetbjzz2017-25-10-18

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (10) : 1041-1044. DOI: 10.11852/zgetbjzz2017-25-10-18

Study on the effectiveness and safety of Levetiracetam in the treatment of epilepsy in infants under 2 years old

YE Gao-bo¹,DONG Jian-peng²,LI Dan¹,LIU Yu¹,WANG Xue-ying¹,YANG Lin¹,HUANG Shao-ping¹

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Abstract

Objective To evaluate the efficacy and safety of levetiracetam used in the infants of epilepsy under 2 years old. Methods A total of 39 patients who were diagnosed with epilepsy,under the age of 2,taken the levetiracetam,hospitalized in pediatric neurological from January 2010 to December 2011 were retrospectively evaluated.Seizure type,family history and imaging were collected.Patients were followed up for 6~72 months to evaluate the treatment condition,efficacy and adverse reactions. Results The treatment dosage in monotherapy group was mainly given as a lower dosage (82.7%),while that in add-on therapy group was mainly in high doses (70%).After 6 months' follow-up,the total effective rate was 82.1%,and the total control rate was 61.5%.Among them,the efficacy rates in focal seizure and the tonic-clonic seizure were 76% and 55.6%.The levetiracetam may be useless on the atonic seizure and myoclonic seizure.Also,the adverse reactions rarely occurred,suggesting that the levetiacetam was safe. Conclusion Levetiracetam is a broad-spectrum antiepileptic drug and has high tolerance and retention rate.It is promising to be a helpful choice for the epilepsy children within 2 years old.

Key words

epilepsy / Levetriacetam / infant

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YE Gao-bo,DONG Jian-peng,LI Dan,LIU Yu,WANG Xue-ying,YANG Lin,HUANG Shao-ping. Study on the effectiveness and safety of Levetiracetam in the treatment of epilepsy in infants under 2 years old[J]. Chinese Journal of Child Health Care. 2017, 25(10): 1041-1044 https://doi.org/10.11852/zgetbjzz2017-25-10-18

References

[1] 沈晓明,王卫平.儿科学[M].北京:人民卫生出版社,2008:182-184.
[2] Kanemura H,Sano F,Tando T,et al.Efficacy and safety of add-onlevetiracetam in refractory childhood epilepsy[J].Brain and Development,2013,35(5):386-391.
[3] Robert S,Carlos A,Alexis A,et al.A practical clinical definition of epilepsy[J].Epilepsia,2014,1:1-8.
[4] Kwan P,Brodie MJ.Early identification of refractory epilepsy[J].N Engl J Med,2000,342(5):314-319.
[5] Brodie MJ,Barry SJ,Bamagous GA,et al.Patterns of treatment response in newly diagnosed epilepsy[J].Neurology,2012,78(20):1548-1554.
[6] 刘腾.左乙拉西坦的药理和临床评价[J].中国新药杂志,2007,16(9):733-735.
[7] Mohamad Z,Koubeissi MD.Monotherapy in newly diagnosed epi-lepsy:Levetiracetam versus standard anticonvulsants[J].Epilepsy Currents,2014,14(5):255-256.
[8] Pina-Garzn JE,Schiemann-Delgado J,Yang H,et al.Adjunctive levertiracetam in patients aged 1 month to <4 years with partial onset seizures:subpopulation analysis of a prospective,open label extension study of up to 48 weeks[J].Clin Ther,2010,32(11):1935-1950.
[9] Li J,Xiao N,Chen S.Efficacy and tolerability of levetiracetam in children with epilepsy[J].Brain & Development,2011,33(2):145-151.
[10] Pina-Garzn JE,Schiemann-Delgado J,Yang H,et al.Adjunctive levertiracetam in patients aged 1 month to <4 years with partial onset seizures:subpopulation analysis of a prospective,open label extension study of up to 48 weeks[J].Clin Ther,2010,32(11):1935-1950.
[11] 李立敏,王宁,胡海鹏,等.左乙拉西坦治疗儿童癫痫疗效观察[J].山东医药,2016,54(2):80-81.
[12] Lee YJ,Kang HC,Kim HD,et al.Efficacy and safety of adjunctive levetiracetam therapy in pediatric intractable epilepsy[J].Pediatr Neurol,2010,42(2):86-92.
[13] güder R,Güzel O,A

In H,et al.Efficacy and safety of IV levetiracetam in children with acute repetitive seizures[J].Pediatric Neurology,2014,51(5):688-695.
[14] Gujjar AR,Nandhagopal R,Jacob PC,et al.Intravenous levetiracetam vs phenytoin for status epilepticus and cluster seizures:A prospective,randomized study[J].Seizure,2017,49:8-12.
[15] Tekgül H,Gencpinar P,avuo

lu D,et al.The efficacy,tolerability and safety of levetiracetam therapy in a pediatric population[J].Seizure,2016,36:16-21.
[16] Grosso S,Franzoni E,Coppola G,et al.Efficacy and safety of levetiracetam:an add-on trial in children with refractory epilepsy[J].Seizure,2005,14(4):248-253.
[17] Xiao F,An D,Deng H,et al.Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS)[J].Seizure,2014,23(9):756-761.