Research of early use of antibiotics in infants and increasing risk of obesity in children

JIA Yan-yan; REN Li-hong

doi:10.11852/zgetbjzz2017-25-10-17

PDF(394 KB)

Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (10) : 1038-1040. DOI: 10.11852/zgetbjzz2017-25-10-17

Research of early use of antibiotics in infants and increasing risk of obesity in children

JIA Yan-yan,REN Li-hong

Author information +

History +

Abstract

Obesity is one of the important problems that threaten the health of human in the 21st century.And the prevalence of childhood obesity has become more and more concerned by people.Early use of antibiotics in infants may lead to weight gain in childhood.This mechanism may be related to the destruction of normal intestinal flora by antibiotics.Early intestinal flora colonization in infants is essential to the metabolism of the body,and it may also be related to the occurrence and development of the disease.Developing the strategy of bacterial recovery after antibiotic treatment to balance the intestinal flora and to promote the healthy growth and development of the body,may become a new research direction for the early prevention of obesity.This article reviews recent studies regarding intestinal flora and obesity.

Key words

early stage / antibiotics / intestinal flora / obesity / infants

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

JIA Yan-yan,REN Li-hong. Research of early use of antibiotics in infants and increasing risk of obesity in children[J]. Chinese Journal of Child Health Care. 2017, 25(10): 1038-1040 https://doi.org/10.11852/zgetbjzz2017-25-10-17

References

[1] Wright GD.Antibiotic adjuvants:rescuing antibiotics from resistance[J].Trends Microbiol,2016,24(11):862-871.
[2] Saari A,Virta LJ,Sankilampi U,et al.Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life[J].Pediatrics,2015,135(4):617-626.
[3] Munyaka PM,Khafipour E,Ghia JE.External influence of early childhood establishment of gut microbiota and subsequent health implications[J].Front Pediatr,2014,2:109.
[4] Cho I,Yamanishi S,Cox L,et al.Antibiotics in early life alter the murine colonic microbiome and adiposity[J].Nature,2012,488(7413):621-626.
[5] Ferrer M,Santos VAMD,Moya SJOA.Gut microbiota disturbance during antibiotic therapy:a multi-omic approach[J].Gut,2013,62(11):1591-601.
[6] Cox LM,Yamanishi S,Sohn J,et al.Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences[J].Cell,2014,158(4):705-721.
[7] Cani PD,Bibiloni R,Knauf C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes,2008,57(6):1470-1481.
[8] Morel FB,Oosting A,Piloquet H,et al.Can antibiotic treatment in preweaning rats alter body composition in adulthood?[J].Neonatology,2013,103(3):182-189.
[9] Goulet O.Potential role of the intestinal microbiota in programming health and disease[J].Nutrition Reviews,2015,73(Suppl1):32-40.
[10] Tremaroli V,B ckhed F.Functional interactions between the gut microbiota and host metabolism[J].Nature,2012,489(7415):242-249.
[11] Ajslev T A,Andersen C S,Gamborg M,et al.Childhood overweight after establishment of the gut microbiota:the role of delivery mode,pre-pregnancy weight and early administration of antibiotics[J].Int J Obes,2011,35(4):522-529.
[12] Pérezcobas AE,Artacho A,Knecht H,et al.Differential effects of antibiotic therapy on the structure and function of human gut microbiota[J].Plos One,2013,8(11):1434-1434.
[13] Azad MB,Bridgman SL,Becker AB,et al.Infant antibiotic exposure and the development of childhood overweight and central adiposity[J].Int J Obes,2014,38(10):1290-1298.
[14] Trasande L,Blustein J,Liu M,et al.Infant antibiotic exposures and early-life body mass[J].Int J Obes,2012,37(1):16-23.
[15] Murphy R,Stewart AW,Braithwaite I,et al.Antibiotic treatment during infancy and increased body mass index in boys:an international cross-sectional study[J].Int J Obes,2014,38(8):1115-1119.
[16] Trehan I,Goldbach HS,Lagrone LN,et al.Antibiotics as part of the management of severe acute malnutrition[J].New England Journal of Medicine,2015,7(2):177-186.
[17] Gough EK,Moodie EE,Prendergast AJ,et al.The impact of antibiotics on growth in children in low and middle income countries:systematic review and meta-analysis of randomised controlled trials[J].Bmj,2014,348(8):584.
[18] Park DY,Ahn YT,Park SH,et al.Supplementation of lactobacillus curvatus HY7601 and lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity[J].Plos One,2013,8(3):e59470-e59470.
[19] Hill C,Guarner F,Reid G,et al.The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J].Nat Rev Gastroenterol Hepatol,2014,11(8):506-514.
[20] Mekkes MC,Weenen TC,Brummer RJ,et al.The development of probiotic treatment in obesity:a review[J].Benef Microbes,2014,5(1):19-28.