Objectives To understand the association of air pollutants with preterm birth in Xuhui District and to quantitatively evaluate the effect of air pollutants (PM10,SO2,and NO2) on preterm birth. Method A generalized additive model (GAM) was used to analyse the association of air pollutants (PM10,SO2,and NO2) with preterm delivery after controlling confounders including the covariates of temperature,humidity and day of week (DOW). Results A significant effect of PM10 was observed only in 1-week exposure before preterm birth.An increase of 10 μg/m3 of 1-week average PM10 corresponded to 1.868% (95%CI:0.339%~3.397%) higher rate of preterm birth.NO2,with 1-week,2-week and 3-week exposure before delivery,was statistically significant with preterm birth and with the NO2 rising per 10 μg/m3,the incidence of preterm birth was up to 6.241%(95%CI:2.294% ~10.134%),7.098% (95%CI:2.100%~12.096%) and 6.498% (95%CI:0.344%~12.652%)respectively.Otherwise,SO2 had no signficant impact on the premature occurrence.After stratified by maternal age,birth defects,and number of births,the stronger associations with PM10 in the levels of single birth,infants who had birth defects,maternal age below 24 and over 34 years old,were considered.NO2 was related to preterm birth only at the level of maternal age over 34 years old.The effect of SO2 on premature was not observed within each group.Studies of acute effects were also overtaken.In the analysis of pollutants,only NO2 with lag4 and lag5 exhibited an effect on preterm birth. Conclusions The influences of air pollutants PM10 and NO2 are statistically significant on preterm birth.The effect of exposure of 3 weeks before birth is more meaningful than acute effect.The impact of SO2 on premature is not found.
Key words
air pollution /
PM10 /
SO2 /
NO2 /
preterm birth /
time-series
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