Objective To explore the influencing factors of intestinal microbial colonization resistance among infants and young children in Shaanxi province,and to provide scientific basis for enhancing the colonization resistance. Methods A case control study by 1∶1 design was employed in this research,with equivalent number of diarrhea and healthy children stratified by month of age.Structured questionnaires were used to collect the sociodemographic characteristics,feeding patterns and information associated with the prevalence of diarrhea,stool samples of young children were collected as well.The structure and diversity of microbial communities in feces were detected by Illumina sequencing. Results Sociodemographic characteristics such as residential type (Z=4.57,P＜0.001),delivery mode (Z=2.75,P=0.01),mother's level of education (Z=1.72,P=0.04),diarrhea (F=2.357,P=0.076) and supplementary pattern (F=5.976,P=0.001),were significantly associated with intestinal microbial colonization resistance of infants.Diversity of intestinal microbiota was positively correlated with colonization resistance. Conclusions Improving mother's education,advocating natural birth,and popularizing scientific and rational feeding pattern could enhance the intestinal microbial colonization resistance in infants and young children.
Key words
intestinal microbiota /
colonization resistance /
young children
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