Objective To investigate the outcomes and prognosis of autistic children by follow-up visiting children with positive autism caution index (CI) within 1 year for 3 years.Methods In the high-risk outpatient department,the follow-up examination,family intervention guidance,regular evaluation and 3-year follow-up visiting were conducted in the children with positive autism alert index according to the Autism Diagnosis and Rehabilitation Guide issued by the Ministry of Health in 2010.The Children Autism Rating Scale (CARS) and the Gesell Development Scale were tested in the children with autism (experimental group) and the random outpatient children at the same age (control group),and result of each group were analyzed.Results 30 autism spectrum disorders were diagnosed out of 35 high-risk patients,and 5 were diagnosed with others including 2 cases of mental retardation,1 case of congenital pigment incontinence,1 case of tuberous sclerosis,1 case of congenital blind child.The CARS score of the ASD children was lower than that of the control group (P<0.001).The Gesell development scale test showed that the children with ASD had a higher CARS score than the control group (P<0.001).The five energy levels of the two groups were both lower than normality,but each energy level of the control group was lower than that of the experimental group (P<0.001).Conclusion It is feasible to use infant early warning indicators of autism spectrum disorders to screen children with autism early,which is helpful to reduce the severity of autism and to improve the ability of autistic children.