Objective To analyze the risk factors in Uighur children with cerebral palsy (CP) in Xinjiang,and to provide clinical evidence to the prevention and treatment of CP.Methods A total of 286 Uighur children with CP and 572 healthy Uighur children (0~6 years old) were collected from Xinjiang autonomous region people's hospital during Jan.2013 to Jun.2015.The risk factors of CP was analyzed by single factor and multiple-factor logistic analysis method.Results Single factor logistic analysis showed that the incidence of CP correlated with genetic factor and various antenatal,intrapartum and postpartum factors.Multiple-factor logistic analysis showed that the risk factors of CP mainly contained intermarriage,family history of encephalopathy,pregnant infection,negative reproductive history,gestational age <32 weeks,fetal distress,low birth weight,neonatal asphyxia,neonatal severe jaundice and newborn hypoxia ischemia.Conclusions The incidence of CP for Xinjiang Uighur children is related to multiple risk factors,the prevention and intervention of each risk factors should be strengthened to reduce the incidence of CP in children.
Key words
cerebral palsy /
risk factor /
children
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 陈秀洁,李树春.小儿脑性瘫痪的定义、分型和诊断条件[J].中华物理医学与康复杂志,2007,29(5):309.
[2] Moreno-De-Luca A,Ledbetter DH,Martin CL.Genetic insights into the causes and classification of the cerebral palsies[J].Lancet Neurol,2012,11(3):283-292.
[3] O'Leary P,Maxwell S,Sinosich M,et al.Screening for Down syndrome in the second trimester of pregnancy[J].Australian & New Zealand Journal of Obstetrics & Gynaecology,2016,56(1):19-21.
[4] 徐晓莉,肖农,赵阳.脑瘫研究的一些新进展[J].中华物理医学与开发杂志,2012,34(5):393-395.
[5] Laskin MD,Yinon Y,Whittle WL.Preterm premature rupture of membranes in the presence of cerclage:is the risk for intra-uterine infection and adverse neonatal outcome increased?[J].Journal of Maternal-Fetal & Neonatal Medicine,2012,25(4):424-428.
[6] 刘英华,刘敏娟,陈瑛.单核苷酸多态性关联分析在早产遗传易感性中的研究进展[J].中华实用儿科临床杂志,2013,28(20):1588-1591.
[7] 江倩男,姜红.早产儿脑病相关危险因素回顾性分析[J].实用儿科临床杂志,2011,26(18):1413-1416.
[8] 杨柳,李荔荔,李静,等.小儿脑性瘫痪危险因素的病例对照研究[J].中国儿童保健杂志,2013,21(5):531-534.
[9] 王贵双.新生儿缺氧缺血性脑病综合性治疗的临床分析[J].中国药物与临床,2014,14(1):108-110.
[10] McIntyre S,Taitz D,Keogh J,et al.A systematic review of risk factors for cerebral palsy in children born at term in developed countries[J].Dev Med Child Neurol,2013,55(6):499-508.
[11] 顾秀玲,严宏菲,魏航.332例脑瘫患儿病因及相关因素分析[J].中国医药导报,2011,8(14):153-158.
[12] 胡会芹.痉挛型脑瘫患儿发病的相关因素研究[J].中国实用神经疾病杂志,2014,17(20):12-14.
[13] Wang LW,Lin YC,Wang ST,et al.Hypoxic/ischemic and infectious events have cumulative effects on the risk of cerebral palsy in very-low-birth-weight preterm infants[J].Neonatology,2014,106(3):209-215.
[14] Thapa R.Retrospective descriptive study of cerebral palsy in nepal[J].Journal of Autism and Developmental Disorders,2016,46(7):2285-2291.
[15] 刘卫鹏,屈素清,栾佐.重症脑瘫240例临床分析[J].中国儿童保健杂志,2013,21(8):862-864.
[16] 彭素华,李静,吴樊,等.68例小儿脑性瘫痪的危险因素分析[J].中华全科医学,2016,14(7):1163-1165.