Objective To investigate the application of the ages and stages questionnaires in high-risk infants systematic management,and to provide evidences for building a more efficient system management mode. Methods A total of 252 high-risk infants who were born in a community from March 2012 to March 2013 were divided into two groups:the 125 cases who were selected as the observation group were examined by the ages and stages questionnaires in important period of the growth,the other 127 cases as a control group were examined by the original systematic management.After 2 years of follow- up,the follow-up rate,the referral rate,the intelligence development level and social-emotional level related to the future quality of life were analyzed. Results The follow-up rate of observation group was 92.8%,and the referral rate was 43.2%,which were higher than those of control group,the difference was statistically significant (P<0.05).The intelligence development level of observing group score (90.25±3.16),higher than that of high-risk infants in the control group,the difference was statistically significant (P<0.01).Social-emotional score (65.91±1.03),below the control group,the difference was statistically significant (P<0.05). Conclusion The application of the ages and stages questionnaires in of high-risk infants systematic management can improve the follow-up rate and referral rate of high-risk infants,raising the level of intelligence and social-emotional ability in high-risk infants,and then improve the quality of survival in high-risk infants.