Objective To explore influencing factors of weight growth rate of preterm infants post-discharge of hospital in half a year,and to provide the theoretical basis for improving the life quaity of premature infants. Methods A total of 174 premature infants were followed up from 2012 to 2014 at the following-up center of high-risk children in our hospital,with physique development parameters monitored per month till six months after discharge from the hospital.At the mean time,base line data were collected,such as gestational age,birth weight,complications,high risk factors,family back ground,etc.Multiple regression analysis was in application of analyzing the impact factors. Results ANOVA analysis showed there was difference at feeding styles,gender,small for gestational age and preterm infant classification,and it was statically significant(P<0.05).There was no significant difference at birth weight,delivery age,infant complication and pregnancy complication respectively(P>0.05).Multiple regression analysis indicated that main influencing factors of body weight growth rate of the post-charge hospital premature infants included gestational age,small for gestational age,gender and feeding style. Conclusion Personalized nutrition formula may have a far-reaching influence on weight catch-up of preterm infants.