Objective To explore the early diagnostic value of brainstem auditory evoked potential(BAEP) and magnetic resonance imaging(MRI) in the neonates with bilirubin encephalopathy. Methods Retrospective analysis of the relared clinical indicators in 137 neonates with hyperbilirubinemia. Results The levels of serum total bilirubin,serum total bilirubin/albumin were higher in the neonates with abnormal BAEP,abnormal MRI and acute bilirubin encephalopathy than those with normal BAEP,normal MRI and without cute bilirubin encephalopathy (P<0.05).Abnormal rate of BAEP was positively correlated to that of MRI (r=0.466,P<0.05).On the diagnosis of bilirubin encephalopathy,the sensitivity of BAEP(87.18%) was higher than MRI (64.10%),but the specificity of BAEP(78.57%) was lower than MRI(93.88%). Conclusion BAEP and MRI examinations have important clinical value in the early diagnosis of bilirubin encephalopathy in the neonates.
Key words
hyperbilirubinemia /
bilirubin encephalopathy /
brainstem auditory evoked potential /
magnetic resonance imaging
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References
[1] 张健,郑洪,刘光辉,等.新生儿胆红素脑病的早期诊断及神经损伤的综合评价[J].中国妇幼健康研究,2014,25(2):184-185.
[2] 中华医学会儿科分会新生儿学组,《中华儿科杂志》编辑委员会.新生儿高胆红素血症诊断和治疗专家共识[J].中华儿科杂志,2014,52(10):745-748.
[3] 中华医学会儿科学分会新生儿学组.中国新生儿胆红素脑病的多中心流行病学调查研究[J].中华儿科杂志,2012,50(5):331-335.
[4] Yu Z,Han S,Wu J,et al.Validation of transcutaneous bilirubin nomogram for identifying neonatal hyperbilirubinemia in healthy Chinese term and late-preterm infants:a multicenter study[J].J Pediatr(Rio J),2014,90(3):273-278.
[5] 新生儿高胆红素血症临床研究协作组.新生儿小时经皮胆红素百分位曲线图预测高胆红素血症价值的多中心临床研究[J].中华儿科杂志,2015,53(11):830-834.
[6] Gowaert P,Lequin M,Swarte R,et al.Changesinglobus with(pre)term kernicterus[J].Pediatrics,2013,112(6):1256-1263.
[7] Campistol J,Galvez H,Cazorla AG,et al.Neurologicaldys function induced by bilirrubin[J].Neurologia,2012,27(4):202-211.
[8] 黄楠楠,王品品.新生儿高胆红素血症脑干听觉诱发电位对听力损害程度的临床评估[J].中国保健营养,2014,24(7):3822-3823.
[9] 刘丽娟,朴梅花,李松.血清游离胆红素的相关因素的研究[J].中国新生儿杂志,2009,24(1):11-14.
[10] 刘辉,潘家华,闵红,等.高胆红素血症新生儿总胆红素/白蛋白比值与脑干听觉诱发电位的关系[J].临床儿科杂志,2011,29(9):841-844.
[11] 周勇,李贵男,庄严,等.血清胆红素水平与胆红素脑病MRI表现的相关性分析[J].临床医学研究,2013,30(10):1973-1975.
[12] 刘丽.急性胆红素脑病发生的高危因素及MRI和BAEP对其诊断的价值[D].南京:中国医科大学,2010.
Funding
苏州市科技计划项目(SYS201442)
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