Status of oxidative stress in children with type 1 diabetes mellitus

ZHAO Yong-xin; XIN Ying

doi:10.11852/zgetbjzz2017-25-07-08

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (7) : 675-678. DOI: 10.11852/zgetbjzz2017-25-07-08

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Status of oxidative stress in children with type 1 diabetes mellitus

ZHAO Yong-xin¹, XIN Ying²

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Abstract

Objective To compare the serum levels of oxidative stress index in type 1 diabetic children and healthy children,and explore the changes of oxidative and anti-oxidative ability of children with type 1 diabetes mellitus. Methods A total of 62 type 1 diabetic children were selected as study cases,and 36 healthy children as normal controls.According to duration and infected situation,the study cases was divided into onset group and little long-term group,infected group and un-infected group.Serum levels of oxidative parameters:malondialdehyde (MDA),nitric oxide (NO),and anti-oxidative parameters:glutathione peroxidase (GPx),superoxide dismutase (SOD) were measured.At the same time,fasting blood glucose,c-peptide,glycosylated hemoglobin (HbA1c),blood urea nitrogen in study cases were detected.The significance and correlation among these parameters were analyzed. Results The serum MDA,NO,SOD levels in study cases were significantly higher than controls (P<0.05),while the levels of serum GPx level in cases was significantly lower than controls (P<0.05).In the onset group,MDA,NO,SOD were significantly higher than controls (P<0.05),GPx was significantly lower than controls,too (P<0.05).There was no significance between infected and un-infected groups(P>0.05).There was a positive correlation between levels of MDA and levels of HbA1c (r=0.376,P<0.01). Conclusion sThe significant increase of oxidative stress and decrease of anti-oxidative capacity occurr at onset and in the development of type 1 diabetes mellitus in children.Oxidative stress may take the important role in type 1 diabetes mellitus of children.

Key words

type 1 diabetes mellitus / oxidative stress / malondialdehyde / glutathione peroxidase / nitric oxide / superoxide dismutase

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ZHAO Yong-xin, XIN Ying. Status of oxidative stress in children with type 1 diabetes mellitus[J]. Chinese Journal of Child Health Care. 2017, 25(7): 675-678 https://doi.org/10.11852/zgetbjzz2017-25-07-08

References

[1] Patterson CC,Dahlquist GG,gyurus E,et al.Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20:a multicentre prospective registration study[J].Lancet,2009,373(9680):2027-2033.
[2] Gyurus EK,Patterson C,Soltesz G,et al.Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary-the rising trend continues (or peaks and highlands[J].Pediatr Diabetes,2012,13(1):21-25.
[3] Wang J,Yang X,Zhang J.Bridges between mitochondrial oxidative stress,ER stress and mTOR signaling in pancreatic βcells[J].Cell Signal,2016,28(8):1099-1104.
[4] Newsholme P,Haber EP,Hirabara SM,et al.Diabetes associated cell stress and dysfunction:role of mitochondrial and non-mitochondrial ROS production and activity[J].J Physiol,2007,583(Pt 1):9-24.
[5] Sakai K,Matsumoto K,Nishikawa T,et al.Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells[J].Biochem Biophys Res Commun,2003,300(1):216-222.
[6] Tian YF,Hsieh CH,Hsieh YJ,et al.α-Lipoic acid prevents mildportal endotoxaemia-induced hepatic inflammation and β cell dysfunction[J].Eur J Clin Invest,2012,42(6):637-648.
[7] Lau YS,Ling WC,Murugan D,et al.Boldine ameliorates vascular oxidative stress and endothelial dysfunction:Therapeutic implication for hypertension and diabetes[J].J Cardiovasc Pharmacl,2015,65(6):297-298.
[8] Lee BW,Kwon SJ,Chae HY,et al.Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells[J].Free Radic Res,2009,43(1):68-77.
[9] Runge MS,Molnar K,Madamanchi NR.“Old” hearts and arteries:the role of oxidative stress[J].Trans Am Clin Climatol Assoc,2010,121(121):52-58.
[10] Lin CC,Huang HH,Hu CW,et al.Trace elements,oxidative stress and glycemic control in young people with type 1 diabetes mellitus[J].J Trace Elem Med Biol,2014,28(1):18-22.
[11] Samahy MHE,Matter RM,Youssef OI,et al.Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents[J].J Diabetes Metab Disord,2013,12(1):50-56.
[12] Fatima N,Faisal SM,Zubair S,et al.Role of Pro-Inflammatory cytokines and biochemical markers in the pathogenesis of type 1 diabetes:correlation with age and glycemic condition in diabetic human subjects[J].PLoS One,2016,11(8):e0161548.doi:10.1371/journal.pone.0161548.
[13] Bandeira MDS,da Fonseca LJSD,Guedes GDS,et al.Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus[J].Int J Mol Sci,2013,14(2):3265-3284.
[14] Dominguez C,Ruiz E,Gussinye M,et al.Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents[J].Diabetes Care,1998,21:1736-1742.
[15] Martín-Gallán P,Carrascosa A,Gussinyé M,et al.Oxidative stress in childhood type 1 diabetes:Results from a study covering the first 20 years of evolution[J].Free Radic Res,2007,41(8):919-928.
[16] Indran M,Rokiah P,Chan SP,et al.Alteration of lipid peroxidation and antioxidant enzymes in young Malaysian IDDM patients[J].Med J Malaysia,2004,59(2):166-170.
[17] Firoozrai M,Nourbakhsh M,Razzaghy-Azar M.Erythrocyte susceptibility to oxidative stress and antioxidant status in patients with type 1 diabetes[J].Diabetes Research and Clinical Practice,2007,77:427-432.