Correlation of vitamin D level with asthma predicting index in infants with recurrent wheeze

LI Ning; ZHOU Qi-xin; GUO Tong

doi:10.11852/zgetbjzz2017-25-06-15

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (6) : 592-595. DOI: 10.11852/zgetbjzz2017-25-06-15

Orignal Article

Correlation of vitamin D level with asthma predicting index in infants with recurrent wheeze

LI Ning, ZHOU Qi-xin, GUO Tong

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Abstract

Objective To investigate the correlation of 25-hydroxy vitamin D[25 (OH)D] level and asthma predicting index (API),and to provide a basis for accurately predicting of the prognosis in infants with recurrent wheezing. Methods The study group consisted of infants with recurrent wheezing which were followed by Pediatrics in Shenzhen Maternity and Child Healthcare Hospital from October 2014 to September 2016.25 (OH)D and total IgE were examined in the participants.The patients were classified into two groups according to API positivity and compared to control subjects(40 normal infants)regarding their 25 (OH)D level and total IgE level.The correlation between API and the level of 25 (OH)D was carried on Pearson correlation analysis. Results The API positive group had the lowest means 25 (OH)D level[(18.97±4.98)ng/ml] followed by API negative group[(23.05±6.32)ng/ml] compared to control group[(27.67±6.82)ng/ml](P<0.05).The API positive group had the highest means IgE level[(192.83±32.36)IU/ml] followed by API negative group[(109.45±12.51)IU/ml] compared to control group[(99.42±18.64)IU/ml] (P<0.05).The incidence of vitamin D deficiency in infants in API positive group (45.71%) is higher than API negative group (23.94%)and control group (17.50%)(P<0.05).There was a negative correlation between the level of total IgE and the level of vitamin D in API positive group(r=-0.727,P<0.05). Conclusions Low level of 25 (OH)D are detected in infants with recurrent wheezing.The 25 (OH)D level is negatively correlated with the levels of total IgE in recurrent wheezing infants with API positive.Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing,and may be an indicator for assessing the risk of their conversion to asthma.

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vitamin D / asthma predicting index / recurrent wheezing / infant

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LI Ning, ZHOU Qi-xin, GUO Tong. Correlation of vitamin D level with asthma predicting index in infants with recurrent wheeze[J]. Chinese Journal of Child Health Care. 2017, 25(6): 592-595 https://doi.org/10.11852/zgetbjzz2017-25-06-15

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