Objective To explore the relationship of single nucleotide polymorphisms(SNP) rs1801282 between PPARγ2 gene and simple obesity in Zhuang nationality children. Methods A total of 285 children(151 cases of simple obese children and 134 healthy control children) in Liuzhou were enrolled.SNP rs1801282 of PPARγ2 gene were detected by SNaPshot assay.Height,weight and biochemical indicator of lipometabolism were measured.Metabolic parameters(FBG,TC,TG,HDL-C and VDL-C) and allele frequency were compared between the two groups. Results The CC and CG+GG genotype frequencies of rs1801282 polymorphism in normal control group and simple obesity group were 95.52%,4.48% and 98.01%,1.99%,respectively.The minor allele frequency(G allelic frequency) in simple obesity group and normal control group were 2.24%,and 0.99%,respectively.The genotype and allelic frequencies of rs1801282 and metabolic parameters(FBG,TC,TG,HDL-C and VDL-C) in simple obese children were not significantly different from those in controls (P>0.05).There were no significantly difference in male group and female group (P>0.05). Conclusions NP rs1801282 of PPARγ2 gene are not associated with simple obesity in Chinese Zhuang preschool children in Liuzhou of Guangxi province.
Key words
PPARγ2 /
genetic polymorphism /
simple obesity /
Zhuang nationality
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