Progress in physiological functions of gut microbiota

ZHENG Yue-jie

doi:10.11852/zgetbjzz2017-25-06-01

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (6) : 541-543. DOI: 10.11852/zgetbjzz2017-25-06-01

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Progress in physiological functions of gut microbiota

ZHENG Yue-jie

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Abstract

The human houses a huge microbe,the commensal microbiota.The collection of all microbial genomes is called the microbiome.A variety of microbiota and microbiome exist throughout the human body,with fundamental roles in human health and disease.The intestinal microbiota and the human host co-exist in a mutually beneficial relationship,which contributes physiological functions,including host resistance to invading pathogens,maturation and homeostasis of the host's immune system,as well as nutrition and metabolism.Disruption of the intestinal commensal microbiota (gut dysbiosis) is associated with a plethora of human diseases,including allergic diseases,autoimmune diseases,metabolic diseases,bacterial infections and colorectal cancer.

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gut microbiota / microbiome / physiological functions

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ZHENG Yue-jie. Progress in physiological functions of gut microbiota[J]. Chinese Journal of Child Health Care. 2017, 25(6): 541-543 https://doi.org/10.11852/zgetbjzz2017-25-06-01

References

[1] 康白,正常微生物群是一个新的人体生理学系统[J].中国微生态学杂志,2003,15(1):63-65.
[2] O'Hara AM,Shanahan F.The gut flora as a forgotten organ[J].EMBO reports,2006,7(7):688-693.
[3] Sommer F,B ckhed F.The gut microbiota-masters of host development and physiology[J].Nat Rev Microbiol,2013,11(4):227-238.
[4] 黄志华,郑跃杰,武庆斌.实用儿童微生态学[M].北京:人民卫生出版社,2014:19-25.
[5] Prakash S,Rodes L,Coussa-Charley M,et al.Gut microbiota:next frontier in understanding human health and development of biotherapeutics[J].Biologics.:Targets and Therapy,2011,5:71-86.
[6] Surana NK,Kasper DL.The yin yang of bacterial polysaccharides:lessons learned from B.fragilis PSA[J].Immunol Rev,2012,245(1):13-26.
[7] Troy EB,Kasper DL.Beneficial effects of Bacteroides fragilis polysaccharides on the immune system[J].Front Biosci (Landmark Ed),2010,15:25-34.
[8] Dowds CM,Blumberg RS,Zeissig S.Control of intestinal homeostasis through crosstalk between natural killer T cells and the intestinal microbiota[J].Clin Immunol,2015,159(2):128-133.
[9] Zeissig S,Blumberg RS.Commensal microbial regulation of natural killer T cells at the frontiers of the mucosal immune system[J].FEBS Lett,2014,588(22):4188-4194.
[10] Jeffery IB,O'Toole PW.Diet-microbiota interactions and their implications for healthy living[J].Nutrients,2013,5(1):234-252.
[11] Rooks MG,Garrett WS.Gut microbiota,metabolites and host immunity[J].Nat Rev Immunol,2016,16(6):341-352.
[12] Levy M,Blacher E,Elinav E.Microbiome,metabolites and host immunity[J].Curr Opin Microbiol,2016,35:8-15.
[13] Yano JM,Yu K,Donaldson GP,et al.Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J].Cell,2015,161(2):264-276.
[14] Gill SR,Pop M,Deboy RT,et al.Metagenomic analysis of the human distal gut microbiome[J].Science,2006,312(5778):1355-1359.
[15] Kang MJ,Kim HG,Kim JS,et al.The effect of gut microbiota on drug metabolism[J].Expert Opin Drug Metab Toxicol,2013,9(10):1295-1308.
[16] Forslund K,Hildebrand F ,Nielsen T,et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J].Nature,2015,528(7581):262-266.
[17] Alexander JL,Wilson ID,Teare J,et al.Gut microbiota modulation of chemotherapy efficacy and toxicity[EB/OL].Nat Rev Gastroenterol Hepatol,2017.doi:10.1038/nrgastro.2017.20.[Epub ahead of print].
[18] Zheng X,Zhao A,Xie G,et al.Melamine-induced renal toxicity is mediated by the gut microbiota[J].Sci Transl Med,2013,5(172):172ra22.