Genes related to masqueraders of dystonic cerebral palsy

FENG Huan-huan; PANG Wei

doi:10.11852/zgetbjzz2017-25-05-14

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (5) : 481-485. DOI: 10.11852/zgetbjzz2017-25-05-14

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Genes related to masqueraders of dystonic cerebral palsy

FENG Huan-huan, PANG Wei

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Abstract

Cerebral palsy (CP) is heterogeneous with different clinical types,comorbidities,brain imaging patterns,causes,and now also heterogeneous underlying genetic variants.Epidemiological studies have shown that the origins of most CP are prior to labor.Clinical risk factors could act as triggers for CP where there is genetic susceptibility,such as preterm delivery,intrauterine infection,and so on.However,some movement disorders were misdiagnosed as CP in practice due to the coincident characteristics of "dystonia",representing spastic,ataxic or dyskinetic phenotype.Recently with the rapid development of molecular genetics (chromosome microarrays and second generation sequencing technology),an unprecedented number of new dystonia genes have recently been described.Here,genes of CP masqueraders were labelled as "symptamatic genes of CP" correspond to susceptibility genes,reviewed the progress of research and provided a reference for the survey,especially the genetic etiology of subsequent dystonia.

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cerebral palsy / genetic factors / symptamatic genes

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FENG Huan-huan, PANG Wei. Genes related to masqueraders of dystonic cerebral palsy[J]. Chinese Journal of Child Health Care. 2017, 25(5): 481-485 https://doi.org/10.11852/zgetbjzz2017-25-05-14

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