Evaluation on the vitamin D status of breastfed infants from 0 to 6 month-old

LI Na; HUANG Wen-qing; LIU Tao; ZHANG Wei

doi:10.11852/zgetbjzz2017-25-04-22

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (4) : 398-400. DOI: 10.11852/zgetbjzz2017-25-04-22

Evaluation on the vitamin D status of breastfed infants from 0 to 6 month-old

LI Na,HUANG Wen-qing,LIU Tao,ZHANG Wei

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Abstract

Objective To investigate vitamin D status of 0~6 month-old breastfeeding infants in Beijing area and the relationships between 25(OH)D,PTH and BAP. Methods Mother-infant pairs were recruited.All breastfed infants receive a daily vitamin D supplement of 400 IU.Venous blood was collected and the levels of serum 25(OH)D,PTH and BAP were also measured when infants were born and 4 months and 6 months of age. Results At 0 month group,only a small part of infants whose (28.8%) vitamin D level were in normal range,and the proportion rose to 82.8% when they were 4 months old,and 83% at 6 months of age.There was a significantly positively correlation of serum 25(OH)D between 0 month group and 4 months group (r=0.418,P＜0.01).At 4 months group,serum 25(OH)D was inversely correlated with both BAP and PTH (r=-0.485 and -0.216,P＜0.05). Conclusions Vitamin D status of newborn in Beijing is low,but most of breastfeeding infants can have a good vitamin D status through a daily vitamin D supplement of 400 IU.Neonatal vitamin D reserves may affect the vitamin D levels of their early days.

Key words

vitamin D deficiency / breastfed infants / vitamin D supplement / parathyroid hormone / bone alkaline phosphatase

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LI Na,HUANG Wen-qing,LIU Tao,ZHANG Wei. Evaluation on the vitamin D status of breastfed infants from 0 to 6 month-old[J]. Chinese Journal of Child Health Care. 2017, 25(4): 398-400 https://doi.org/10.11852/zgetbjzz2017-25-04-22

References

[1] Taylor JA,Geyer LJ,Feldman KW.Use of supplemental vitamin D among infants breastfed for prolonged periods[J].Pediatrics,2010,125(1):105-111.
[2] You JC,Moon KK,Su JJ.Vitamin D deficiency in infants aged 1 to 6 months[J].Korean J Pediatr,2013,56(5):205-210.
[3] Misra M,Pacaud D,Petryk A.Drug and therapeutics committee of the lawson wilkins pediatric endocrine society:vitamin D deficiency in children and its management:review of current knowledge and recommendations[J].Pediatrics,2008,122(2):398-417.
[4] Braegger C,Campoy C,Colomb V.VitaminD in the healthy European paediatric population[J].J Pediatr Gastroenterol Nutr,2013,56(6):692-701.
[5] Lamberg-Allardt C,Brustad M,Meyer HE.Vitamin D-A systematic literature review for the 5th edition of the Nordic Nutrition Recommendations[J].Food Nutr Res,2013,57(3):1-31.
[6] Sina G,Kathryn C,Catherine V,Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy,breastfed infants[J].JAMA,2013,309(17):1785-1792.
[7] Viljakainen HT,Saarnio E,Hytinantti T.Vitamin D status determines bone variables in the newborn[J].J Clin Endocrinol Metab,2010,95(4):1749-1757.
[8] Kumar P,Shenoi A,Kumar RK.Vitamin D deficiency among women in labor and cord blood of newborns[J].Indian Pediatr,2015,52(6):530-531.
[9] Holick MF,Binkley NC,Bischoff-Ferrari HA,et al.Evaluation,treatment,and prevention of vitamin deficiency:an Endocrine Society clinical practice guideline[J].J Clin Endocrinol Metab,2011,96(7):1911-1130.
[10] Ross AC,Manson JE,Abrams SA,et al.The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine:what clinicians need to know[J].J Clin Endocrinol Metab,2011,96(1):53-58.
[11] Craig FM,Nick S,Mairead K,Global consensus recommendations on preventionand management of nutritional rickets[J].J Clin Endocrinol Metab,2016,101(2):394-415.
[12] 黄文卿,范玲,刘韬,等.妊娠晚期血清25羟维生素D3与胰岛素抵抗及骨代谢相关研究[J].中华临床医师杂志,2013,7(4):1445-1449.
[13] Mitchell,Juppner.Regulation of calcium homeostasis and bone metabolism in the fetus and neonate[J].Curr Opin Endocrinol Diabetes Obes,2010,17:25-30.
[14] Daphna K,Janet C,Ellen B.Evidence of associations between feto-maternal vitamin D status,cord parathyroid hormone and bone-specific alkaline phosphatase,and newborn whole body bone mineral content[J].Nutrients,2012,4:68-77.
[15] Atapattu N,Shaw N,Hgler W.Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children[J].Pediatr Res,2013,74(5):552-556.