Objective To research the relationship between the level of insulin-like growth factor-I (IGF-I) and the nutrition state of children with functional dyspepsia. Methods A total of 50 cases of children with functional dyspepsia were selected as the observation group,and 50 cases of healthy children as the control group,both of whom were within 1~7 years old.The levels of serum IGF-I,PA,RBP,TRF,ALB and FFA were checked on each single child and analysis data were rendered and processed by means of SPSS18.0 statistical software. Results The level of serum IGF-I of the functional dyspepsia children was significantly lower than that of the healthy children,nutrition indicators of PA,RBP,TRF also were lower than those of the healthy children( t values were 7.60,5.00,2.50,2.40,P<0.05),but there were not obvious differences of free fatty acids and ALB (t values were 0.15、1.1,P>0.05). Conclusions Children with functional dyspepsia have a digestive disturbance,the barrier of children's absorption of nutrients disorder,and reduction of PA,RBP,TFR,which leads to decrease the serum IGF-I content.Lower level of IGF-I will affect growth and development of the functional dyspepsia children.