Prevention and treatment of lead poisoning in children—A review with recent updates

GUO Yan; WU Xiao-yan; XIONG Wei; HUI Chang-ye

doi:10.11852/zgetbjzz2017-25-04-16

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (4) : 378-381. DOI: 10.11852/zgetbjzz2017-25-04-16

Prevention and treatment of lead poisoning in children—A review with recent updates

GUO Yan,WU Xiao-yan,XIONG Wei,HUI Chang-ye

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Abstract

Lead,a systemic toxicant,primarily affects the central nervous system,particularly the developing brain.There is not a safe level of lead exposure for children,the intervention level is often interpreted as a threshold.Children lead poisoning has become a public health problem of global magnitude and concern.The prevalence and severity of childhood lead poisoning have been greatly reduced since the removal of lead from environment in China recently.Primary prevention consists of health education and avoidance of lead-contaminated products,and chelation therapy with necessary.Metal-chelating agent has been used for many years,but the potential risks of administration chelator to children exist.Oral exposure represents the most significant route of lead intake for children.Blocking the intestinal absorption of lead will be one of new measures for prevention and treatment of lead poisoning in children.

Key words

lead poisoning in children / lead exposure / chelation treatment / lead elimination by the digestive system

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GUO Yan,WU Xiao-yan,XIONG Wei,HUI Chang-ye. Prevention and treatment of lead poisoning in children—A review with recent updates[J]. Chinese Journal of Child Health Care. 2017, 25(4): 378-381 https://doi.org/10.11852/zgetbjzz2017-25-04-16

References

[1] Flegal AR,Smith DR.Lead levels in preindustrial humans[J].N Engl J Med,1992,326(19):1293-1294.
[2] Liu J,Lewis G.Environmental toxicity and poor cognitive outcomes in children and adults[J].J Environ Health,2014,76(6):130-138.
[3] Li MM,Cao J,Gao ZY,et al.The trend of lead poisoning rate in Chinese population aged 0-18 years old:a meta-analysis[J].BMC Public Health,2015,15(1):756.
[4] Cao J,Li M,Wang Y,et al.Environmental lead exposure among preschool children in Shanghai,China:blood lead levels and risk factors[J].PLoS One,2014,9(12):e113297.
[5] van der Kuijp TJ,Huang L,Cherry CR.Health hazards of China's lead-acid battery industry:a review of its market drivers,production processes,and health impacts[J].Environ Health,2013,12:61.
[6] Guo P,Xu X,Huang B,et al.Blood lead levels and associated factors among children in Guiyu of China:a population-based study[J].PLoS One,2014,9(8):e105470.
[7] Sanders T,Liu Y,Buchner V,et al.Neurotoxic effects and biomarkers of lead exposure:a review[J].Rev Environ Health,2009,24(1):15-45.
[8] Monnet-Tschudi F,Zurich MG,Boschat C,et al.Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases[J].Rev Environ Health,2006,21(2):105-117.
[9] Murata K,Iwata T,Dakeishi M,et al.Lead toxicity:does the critical level of lead resulting in adverse effects differ between adults and children?[J].J Occup Health,2009,51(1):1-12.
[10] Chiodo LM,Jacobson SW,Jacobson JL.Neurodevelopmental effects of postnatal lead exposure at very low levels[J].Neurotoxicol Teratol,2004,26(3):359-371.
[11] Garza A,Vega R,Soto E.Cellular mechanisms of lead neurotoxicity[J].Med Sci Monit,2006,12(3):RA57-65.
[12] Flora G,Gupta D,Tiwari A.Toxicity of lead:A review with recent updates[J].Interdiscip Toxicol,2012,5(2):47-58.
[13] Bechara EJ,Dutra F,Cardoso VE,et al.The dual face of endogenous alpha-aminoketones:pro-oxidizing metabolic weapons[J].Comp Biochem Physiol C Toxicol Pharmacol,2007,146(1-2):88-110.
[14] Patrick L.Lead toxicity,a review of the literature.Part 1:Exposure,evaluation,and treatment[J].Altern Med Rev,2006,11(1):2-22.
[15] Flora SJ,Flora G,Saxena G,et al.Arsenic and lead induced free radical generation and their reversibility following chelation[J].Cell Mol Biol,2007,53(1):26-47.
[16] Lin S,Wang X,Yu IT,et al.Environmental lead pollution and elevated blood lead levels among children in a rural area of China[J].Am J Public Health,2011,101(5):834-841.
[17] Ahamed M,Siddiqui MK.Environmental lead toxicity and nutritional factors[J].Clin Nutr,2007,26(4):400-408.
[18] Gottesfeld P.Time to ban lead in industrial paints and coatings[J].Front Public Health,2015,3:144.
[19] Legagneux P,Suffice P,Messier JS,et al.High risk of lead contamination for scavengers in an area with high moose hunting success[J].PLoS One,2014,9(11):e111546.
[20] Rogers ML,Lucht JA,Sylvaria AJ,et al.Primary prevention of lead poisoning:protecting children from unsafe housing[J].Am J Public Health,2014,104(8):e119-124.
[21] Smith D,Strupp BJ.The scientific basis for chelation:animal studies and lead chelation[J].J Med Toxicol,2013,9(4):326-338.
[22] Dapul H,Laraque D.Lead poisoning in children[J].Adv Pediatr,2014,61 (1):313-333.
[23] Gracia RC,Snodgrass WR.Lead toxicity and chelation therapy[J].Am J Health Syst Pharm,2007,64(1):45-53.
[24] Smith DR,Woolard D,Luck ML,et al.Succimer and the reduction of tissue lead in juvenile monkeys[J].Toxicol Appl Pharmacol,2000,166(3):230-240.
[25] Stangle DE,Strawderman MS,Smith D,et al.Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure[J].Environ Health Perspect,2004,112(3):302-308.
[26] Stangle DE,Smith DR,Beaudin SA,et al.Succimer chelation improves learning,attention,and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure[J].Environ Health Perspect,2007,115(2):201-209.
[27] Khotimchenko M,Kovalev V,Khotimchenko Y.Equilibrium studies of sorption of lead(II) ions by different pectin compounds[J].J Hazard Mater,2007,149(3):693-699.
[28] Tahiri M,Pellerin P,Tressol JC,et al.The rhamnogalacturonan-II dimer decreases intestinal absorption and tissue accumulation of lead in rats[J].J Nutr,2000,130(2):249-253.
[29] Serguschenko I,Kolenchenko E,Khotimchenko M.Low esterified pectin accelerates removal of lead ions in rats[J].Nutrition Research,2007,27:633-639.
[30] Zhao ZY,Liang L,Fan X,et al.The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels[J].Altern Ther Health Med,2008,14(4):34-38.