Objective To investigate measles antibodies level of children in High-tech district of Urumqi and to provide the scientific basis for the development of immunization countermeasures. Methods A total of 560 students aged 3 to 15 were selected from six schools in High-tech district of Urumqi by cluster sampling.The serum IgG levels of measles antibody were detected by ELISA. Results 3~15 years old children's overall measles antibody positive rate was 92.32% in High-tech district of Urumqi.The antibody positive rates were no statistically significant different (P≥0.05) in different groups of different ages,genders,nationalities,places of residence and history of measles disease respectively.The prevalence of measles was 1.43%.The antibody positive rates of different dose were no statistically significant different (P≥0.05).The antibody positive rates of civil population was higher than that of the floating population (P<0.05).The antibody positive rates increased with the growth of age while decreased with the growth of dose vaccination (P<0.05). Conclusion Floating children measles antibody levels remains to be further improved,so the proper supplementary immunization activities (SIAs) implementation is important for elimination of measles.