Comparison study of neuropsychological development between 22q11.2 deletion syndrome and congenital heat disease in early childhood

YAO Hai-li; YAN Dong-yong; SUN Xue-qin; YE Ming; SUN Jin-qiao; WANG Xiao-chuan

doi:10.11852/zgetbjzz2017-25-03-23

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Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (3) : 290-292. DOI: 10.11852/zgetbjzz2017-25-03-23

Comparison study of neuropsychological development between 22q11.2 deletion syndrome and congenital heat disease in early childhood

YAO Hai-li¹,YAN Dong-yong²,SUN Xue-qin²,YE Ming³,SUN Jin-qiao¹,WANG Xiao-chuan¹

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Abstract

Objective To study the effect of congenital heart defects (CHD) on the neuropsychological development of 22q11.2 deletion syndrome (22q11.2DS) in early childhood. Methods Neuropsychological development was evaluated at early childhood using Chinese version of Gesell developmental scales,WPPI-I or WISC-I according to their age.Development quotients (DQ) of each area between two groups were analyzed by independent-sample T-test.The difference of DQ between 22q11.2DS with and without complex CHD was also analyzed. Results The mean age of evaluation of 22q11.2DS group (12 cases,8 male) and CHD-only group (18 cases,9 male) was 32.9 months (from 9 to 89 months) and 22.9 months (from 7 to 74 months) respectively.The mean DQ of gross motor performance,fine motor movement,adaptive behavior,language development and individual social behaviors were mild to moderate disability in 22q11.2DS group,which were 63.5±10.2,65.4±10.7,61.7±9.3,56.7±10.1,60.5±9.7 respectively.The mean DQ of each area of CHD-only group was normal and was higher than that of the 22q11.2DS group significantly.The mean DQ of 5 areas was similar without significant difference statistically comparing between 22q11.2DS with and without complex CHD. Conclusion Neuropsychological development delay is one of the main clinical features of 22q11.2DS in early childhood and could not be affected by CHD and the complexity of CHD.

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22q11.2 deletion syndrome / congenital heart defects / early childhood / neuropsychological development

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YAO Hai-li,YAN Dong-yong,SUN Xue-qin,YE Ming,SUN Jin-qiao,WANG Xiao-chuan. Comparison study of neuropsychological development between 22q11.2 deletion syndrome and congenital heat disease in early childhood[J]. Chinese Journal of Child Health Care. 2017, 25(3): 290-292 https://doi.org/10.11852/zgetbjzz2017-25-03-23

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