Correlation of ADAM33 V4 gene polymorphism and vitamin D levels with asthma children in Urumqi

LV Ji-shou; Jianglihan·aheihati; WANG Jian-rong; CHEN Chun-hua

doi:10.11852/zgetbjzz2017-25-03-10

PDF(538 KB)

Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (3) : 248-250. DOI: 10.11852/zgetbjzz2017-25-03-10

Correlation of ADAM33 V4 gene polymorphism and vitamin D levels with asthma children in Urumqi

LV Ji-shou,Jianglihan·aheihati,WANG Jian-rong,CHEN Chun-hua

Author information +

History +

Abstract

Objective To explore correlation of ADAM33 V4 gene polymorphism and vitamin D (Vit D) level with asthma of children in Urumqi. Method Totally 154 asthmatic children and 120 healthy non-asthmatic children aged 3~15 in Urumqi were selected.ADAM 33 V4 gene single nucleotide polymorphism loci (SNPs) genotyping were detected using PCR polymerase chain reaction and VitD levels were detected by ELISA.Further stratified according ethnic groups were performed and correlation of ADAM33 V4 gene polymorphism and VitD level with asthma were analyzed. Result 1)V4 sites of the frequency distribution of three genotypes between cases and control groups were statistically significant differences (χ²=6.806,P=0.033) and,it showed no significant difference among the different ethnic groups (case group:χ²=0.714,P=0.699;control group:χ²=5.898,P=0.052).2)VitD levels in the case group and the control group were statistically different(t=2.341,P=0.020). Conclusions 1) ADAM33 V4 gene loci is correlated with childhood asthma morbidity in children in Urumqi,but there is no difference among nationalities.V4 site after the G point mutation may be a risk factor of bronchial asthma.2) VitD levels is correlated with childhood asthma morbidity in Urumqi.

Key words

asthma / ADAM33 / V4 loci polymorphism / vitamin D / Urumqi / children

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LV Ji-shou,Jianglihan·aheihati,WANG Jian-rong,CHEN Chun-hua. Correlation of ADAM33 V4 gene polymorphism and vitamin D levels with asthma children in Urumqi[J]. Chinese Journal of Child Health Care. 2017, 25(3): 248-250 https://doi.org/10.11852/zgetbjzz2017-25-03-10

References

[1] 魁艳凤,周宇芳.儿童哮喘的治疗进展[J].吉林医学,2012,33(8):1659-1661.
[2] 中国哮喘儿童家长知信行调查项目组.中国大陆29个城市哮喘患儿病情控制状况及影响因素[J].中华儿科杂志,2013,51(2):90-94.
[3] 金克,多力坤·木扎帕尔,马香萍,等.乌鲁木齐市儿童哮喘患病情况调查及相关因素分析[J].临床儿科杂志,2013,30(6):559-561.
[4] Trepka MJ,Mantin P,Mavunda K,et al.A Pilot asthma incidence surveillance system and case definition:lessons learned[J].Public Health Rep,2009,134(2):267-279.
[5] Van Eerdewegh P,Little RD,Dupuis J,et al.Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness[J].Nature,2002,418(6896):426-430.
[6] Song GG,Kim JH,Lee YH,et al.Association between ADAM33 S2 and ST⁺⁴ polymorphisms and susceptibility to asthma:A meta-analysis[J].Gene,2013,524(1):72-78.
[7] Litonjua AA,Weiss ST.Is Vitamin D deficiency to blamefor the asthmaepidemic[J].J Allergy Clin Immunol,2007,120(5):1031-1035.
[8] Black PN,Scragg R.Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey[J].Chest,2005,128:3792-3798.
[9] 中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会.儿童支气管哮喘诊断和防治指南[J].中华儿科杂志,2008,46(7):745-753.
[10] Trepka MJ,Mantin P,Mavunda K,et al.A Pilot athma incidence surveillance system and case definition:lessons learned[J].Public Health Rep,2009,134(2):267-279.
[11] Kelly HW,Sternberg AL,Lescher R,et al.Eeffect of inhaled glucocorticoids in childhood on adult height[J].N Engl J Med,2012,367(10):904-912.
[12] 李洪涛,于雪峰,李登宇,等.糖皮质激素性骨质疏松症发病机理研究进展[J].中国骨质疏松杂志,2009,15 (2):150-152.
[13] Van Diemen CC,postma DS,Vonk JM,et al.A distintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population[J].Am J Respir Crit Care Med,2005,172:329-333.
[14] Ten BA.Risk factors associated with irreversible airflow limitation in asthma[J].Cur Op in Allergy Clin Immunol,2008,8(1):63-69.
[15] 陈伟伟,蔡栩栩.维生素D与支气管哮喘研究进展[J].国际儿科学杂志,2011,38(4):364-366.