Early prediction and drug therapy of capillary leak syndrome in newborn

SHENG Li-juan; HUANG Wei-min

doi:10.11852/zgetbjzz2017-25-02-14

PDF(473 KB)

Chinese Journal of Child Health Care ›› 2017, Vol. 25 ›› Issue (2) : 158-160. DOI: 10.11852/zgetbjzz2017-25-02-14

Early prediction and drug therapy of capillary leak syndrome in newborn

SHENG Li-juan,HUANG Wei-min

Author information +

History +

Abstract

Capillary leak syndrome (CLS) is one of the common critical cases in NICU.Capillary leak syndrome has high mortality and complex clinical manifestation.It is often neglected due to other complications.Currently,there is no uniform diagnostic criteria.The diagnosis mainly base on clinical manifestation and laboratory examination.The therapeutic principles mainly include controlling the primary disease and fluid resuscitation.Common drugs include antibiotics,hydroxyethyl starch,albumin,blood products,vasoactive agent and so on.Understanding the pathogenesis and clinical manifestations and giving early intervention may improve the survival rate and prognosis of newborns with CLS.

Key words

capillary leak syndrome / newborn / early prediction / drug therapy

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

SHENG Li-juan,HUANG Wei-min. Early prediction and drug therapy of capillary leak syndrome in newborn[J]. Chinese Journal of Child Health Care. 2017, 25(2): 158-160 https://doi.org/10.11852/zgetbjzz2017-25-02-14

References

[1] Dholakia S,Inwald D,Betts H,et al.Endotoxemia in pediatric critical illness-a pilot study[J].Crit Care,2011,15(3):R141.
[2] Kubicki R,Grohmann J,Siepe M,et al.Early prediction of capillary leak syndrome in infants after cardiopulmonary bypass[J].European Journal of Cardio-Thoracic Surgery,2013,44(2):275-281.
[3] Stein DM,Scalea TM.Capillary Leak syndrome in trauma[J].Advances in Surgery,2012,46(1):237-253.
[4] Yabe H,Yabe M,Koike T,et al.Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab[J].Blood,2010,115(13):2723-2724.
[5] Kai-Feng W,Hong-Ming P,Hai-Zhou L,et al.Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia[J].BMC Cancer,2011,11:204.
[6] 隆彩霞,朱之尧,胥志跃,等.儿童脓毒症发生毛细血管渗漏综合征的临床危险因素分析[J].中国当代儿科杂志,2013,15(3):219-222.
[7] Lee WL,Slutsky AS.Sepsis and endothelial permeability[J].N Engl J Med,2010,363(7):689-691.
[8] Nagao Y,Harada H,Yamanaka H,et al.Possible mediators for systemic capillary leak syndrome[J].Am J Med,2011,124(1):e7-e9.
[9] Marx G,Vangerow B,Burczyk C,et al.Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients[J].Intensive Care Medicine,2000,26(9):1252-1258.
[10] Langheinrich AC,Ritman EL.Quantitative imaging of microvascular permeability in a rat model of lipopolysaccharide-induced sepsis:evaluation using cryostatic micro-computed tomography[J].Invest Radiol,2006,41(8):645-650.
[11] Stepina EA,Koposova KA,Khlynova OV,et al.Systemic inflammation markers and microalbuminuria in inflammatory bowel diseases[J].Eksp Klin Gastroenterol,2016(3):15-19.
[12] Assaly RA,Habib RH,Azizi M,et al.Use of multiple fluorophores for evaluating microvascular permeability in control rats and rats with sepsis[J].Clinical Science,2008,114(2):123-130.
[13] Bein B,Meybohm P,Cavus E,et al.The reliability of pulse contour-derived cardiac output during hemorrhage and after vasopressor administration[J].Anesth Analg,2007,105(1):107-113.
[14] Soller B,Srikiatkachorn A,Zou F,et al.Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever[J].BMC Infect Dis,2014,14:396.
[15] Zhou W,Cheng G,Shao X,et al.Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy:a multicenter randomized controlled trial in China[J].The Journal of Pediatrics,2010,157(3):367-372.
[16] Schramko A,Suojaranta-Ylinen R,Niemi T,et al.The use of balanced HES 130/0.42 during complex cardiac surgery; effect on blood coagulation and fluid balance:a randomized controlled trial[J].Perfusion,2015,30(3):224-232.
[17] 王助衡,周冠华,乔薇,等.脉搏指示连续心排血量导管法与肺动脉导管评估血容量的对比研究[J].中国危重病急救医学,2012,24(8):495-496.
[18] Mizobuchi M,Iwatani S,Sakai H,et al.Effect of hydrocortisone therapy on severe leaky lung syndrome in ventilated preterm infants[J].Pediatrics International,2012,54(5):639-645.
[19] Toma A,Stone A,Green RS,et al.Steroids for patients in septic shock:the results of the Corticus trial[J].CJEM,2011,13(04):273-276.
[20] 陈弘,卢洪洲.糖皮质激素在治疗感染性休克中的应用[J].中国实用内科杂志,2009(07):656-658.
[21] Cao YZ,Tu YY,Chen X,et al.Protective effect of Ulinastatin against murine models of sepsis:inhibition of TNF-alpha and IL-6 and augmentation of IL-10 and IL-13[J].Exp Toxicol Pathol,2012,64(6):543-547.
[22] Kiss J,Yegutkin GG,Koskinen K,et al.IFN-beta protects from vascular leakage via up-regulation of CD73[J].Eur J Immunol,2007,37(12):3334-3338.