Objective To investigate the status of the exclusive breastfeeding and analyze the influencing factors among six months infants in Shenzhen,in order to provide a scientific basis for promoting the exclusive breastfeeding. Method A total of 1 000 mothers whose baby within six months were asked to fill in a questionnaire from three maternal and child health hospitals in Shenzhen selected by random sampling. Results The exclusive breastfeeding rate within six months was 61.2%.The main reason for non- exclusive breastfeeding was insufficient breast milk(42.01%).By univariate and multivariate analysis,the results showed that the puerpera with highly educated,high family income,multiparity should less choose the exclusive breastfeeding,and the puerpera with maternity leave,the confidence of the exclusive breastfeeding for six months,family support for breastfeeding,the early time to start breastfeeding,nighttime breastfeeding should more choose the exclusive breastfeeding. Conclusions To further improve the exclusive breastfeeding rate in six months,health education should be strengthened for breastfeeding and postpartum guidance,encourage families to participate,and strengthen the confidence of breastfeeding.Labor units should provide convenience for supporting breastfeeding.The hospital should implement the policy of baby friendly hospital.