Objective To observe the psysical and neurodevelopment in premature infants with respiratory distress syndrome (RDS) of gestational age ＜34 weeks through regular follow-up. Methods A total of 49 premature infants with RDS of gestational age ＜34 weeks and 36 premature infants without RDS of gestational age ＜34 weeks who were followed to twelve months were collected from Qingdao Women and Children's Hospital.They were treated as RDS group and non-RDS group.The RDS patients were divided into the mild RDS group and severe RDS group accoding to severity of illness.A total of 30 full term infants who were randomly selected in the department of child health care were recruited and treated as the full term group.They were followed up once a month at corrected age of 0~6 months and once every 2 months at corrected age of 6~12 months.The Bayley Scale of Infant Development was used to determine the intellectual and neurological development deficits. Results The incidence of extrauterine growth retardation (EUGR) and growth restriction of RDS group was 71.4%,27.5%,20.5%,20.0%,12.1%,8.3% at the time of hospital discharge and corrected age of 1,2,3,6,12 months.The MDI,PDI in RDS group and non-RDS group were significantly lower than those in full term group at corrected age of 6 months (P＜0.05).The abnormal incidence of the 20 items neuromotor assessment in RDS group and non-RDS group was significantly higher than that in full term group (P＜0.05).The PDI in RDS group and non-RDS group was significantly lower than that in full term group at corrected age of 12 months (P＜0.05).The difference of the psysical and neurodevelopment were not significant between RDS group and non-RDS group,the mild RDS group and severe RDS group (P＞0.05). Conclusions The catch-up growth of premature infants with RDS of gestational age ＜34 weeks is significantly within corrected age of 3 months.The psysical and neurodevelopment have no significantly difference between RDS and non-RDS pemature infants.The neurodevelopment of premature infants with RDS of gestational age ＜34 weeks at corrected age of 6 months is poorer than full term infants.
Key words
respiratory distress syndrome /
premature infant;physical development /
neurodevelopment
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2014:396-397.
[2] Sweet DG,Carnielli V,Greisen G,et al.欧洲新生儿呼吸窘迫综合征防治指南-2010版[J].中华儿科杂志,2011,49(1):27-33.
[3] Holme N,Chetcuti P.The pathophysiology of respiratory distress syndrome in neonates[J].Paediatr Child Health,2012,22(12):507-512.
[4] 杨燕玲,单若冰.重度新生儿呼吸窘迫综合征死亡危险因素分析[J].中国小儿急救医学,2014,21(7):423-426.
[5] 崔凤静,杨燕玲,单若冰,等.呼吸窘迫综合征早产儿宫外发育迟缓的危险因素分析[J].中华临床医师杂志:电子版,2014,8(5):883-887.
[6] 韩露艳,王晨,李正红,等.早期营养支持策略对早产儿生长和代谢的影响[J].中国新生儿科杂志,2012,27(5):296-301.
[7] Cooke RJ.Postnatal growth and development in the preterm and small for gestational age infant[J].Nestle Nutr Workshop Ser Pediatr Program,2010,65(1):85-95.
[8] 茹喜芳,冯琪,王颖,等.早产儿体重增长的动态评估及其意义[J].中华儿科杂志.2010,48(9):661-667.
[9] Patrianakos-Hoobler,Athena I,Msall M,et al.Predicting school readiness from neurodevelopmental assessments at age 2 years after respiratory distress syndrome in infants born preterm[J].Developmental Medicine and Child Neurology,2010,52(4):379-385.
PDF(658 KB)
