Objectives To explore the effects and clinical significance of prenatal taurine on IL-6,IL-8,TNF-α and IL-1β in fetal rat brains of intrauterine growth restriction(IUGR). Methods IUGR was induced by food restriction throughout pregnancy.Pregnant rats were randomly divided into 3 groups:control group,IUGR group and taurine group[300 mg/(kg·d)].The expressions of serum IL-6,IL-8,TNF-α and IL-1β in brains were detected by Enzyme linked immunosorbent- assay(ELISA). Results The expressions of IL-6 in control group,test group and taurine group were:(81.070±5.286)pmol/L,(148.362±18.733)pmol/L and (107.361±11.184)pmol/L,there were significant differences among the three groups (H=43.760,P=0.00).The contents of IL-8 in three groups were:(90.573±7.344)pmol/L,(165.596±8.635)pmol/L and (126.309±11.008)pmol/L.There were significant differences among the three groups (H=45.910,P=0.00).The expressions of TNF-α in three groups were:(8.231±0.607)pmol/L,(14.881±0.703)pmol/L and (11.709±0.936)pmol/L,there were significant differences among the three groups (H=45.929,P=0.00).The expressions of IL-1β in three groups were:(46.693±4.122)pmol/L,(84.799±4.315)pmol/L and (62.407±4.631)pmol/L,there were significant differences among the three groups (H=46.064,P=0.00). Conclusion Prenatal taurine can reduce expressions IL-6,IL-8,TNF-α and IL-1β in fetal rat brains of IUGR.
Key words
intrauterine growth restriction /
fetal rat /
taurine /
interleukin-6 /
interleukin-8 /
tumor necrosis factor alpha /
interleukin-1β
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