Objective To examine the association between cesarean section (CS) and the risk of childhood asthma in preschool children. Methods A total of 8 900 children aged from 3 to 6 years old were recruited in Anqing,Wuhu,Tongling and Yangzhou.Data on the mode of delivery,asthma and potential confounders for the present study were obtained by questionnaires completed by the parents or the people who raised the children.All asthma cases were diagnosed by major hospitals.Mode of delivery was classified into vaginal delivery,elective CS and emergency CS.Multivariate logistic regression was used for statistical analyses. Results Of 8 900 preschool children,67.3% were born by cesarean section.The overall prevalence of asthma in the present cross-sectional study was 7.0%,within these children 28.5% were delivered vaginally while 71.5% were delivered by CS.After adjusting for region,sex,preterm birth,maternal age,parental education level,breastfeeding,child body mass index (BMI),children delivered by emergency CS had an increased risk of childhood asthma (OR=1.25,95%CI:1.03~1.52,P<0.05) compared to those delivered vaginally.However,no significant but elevated (OR=1.19,95%CI:0.94~1.51,P>0.05) higher odds of asthma was found in children delivered by elective CS compared to those delivered vaginally. Conclusion Emergency CS increased the risk of childhood asthma in preschool age.
Key words
asthma /
cesarean section /
children /
preschool
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] WHO.Appropriate technology for birth[J].Lancet,1985,2(8452):436-437.
[2] Lumbiganon P,Laopaiboon M,Gülmezoglu AM,et al.Method of delivery and pregnancy outcomes in Asia:the WHO global survey on maternal and perinatal health 2007-2008[J].Lancet,2010,375(9713):490-499.
[3] Rebelo F,da Rocha CM,Cortes TR,et al.High cesarean prevalence in a national population-based study in Brazil:the role of private practice[J].Acta Obstet Gynecol Scand,2010,89(7):903-908.
[4] Cuppari C,Manti S,Salpietro A,et al.Mode of delivery and risk for development of atopic diseases in children[J].Allergy Asthma Proc,2015,36(5):344-351.
[5] At-Khaled N,Pearce N,Anderson HR,et al.Global map of the prevalence of symptoms of rhinoconjunctivitis in children:The international study of asthma and allergies in childhood (ISAAC) phase three[J].Allergy,2009,64(1):123-148.
[6] Bousquet J,Khaltaev N,Bousquet J,et al.Global surveillance,prevention and control of chronic respiratory diseases:A comprehensive approach[J].J Pharm Tech,2008,24(2):122.
[7] Noutsios GT,Floros J.Childhood asthma:causes,risks,and protective factors;a role of innate immunity[J].Swiss Med Wkly,2014,144:w14036.
[8] 全国儿科哮喘协作组,中国疾病预防控制中心环境与健康相关产品安全所.第三次中国城市儿童哮喘流行病学调查[J].中华儿科杂志,2013,51(10):729-735.
[9] Kristensen K,Henriksen L.Cesarean section and disease associated with immune function[J].J Allergy Clin Immunol,2016,137(2):587-590.
PDF(566 KB)
