Peptide is a specifical bioactive substances between amino acids and proteins,which are divided into endogenous peptides and exogenous peptides.Endogenous peptides gain more and more attentions due to the content enrich and various production ways.Recent study revealed that nocoding genes also could code bioactive peptide,and now to find new potential coding open reading frames from lncRNA,rRNA and microRNA is becoming a hot research area.Endogenous peptides could play in many ways,such as binding to its receptor after secretion or working intracellular.As the more application of peptide in the clinic as drugs,there is no doubt that endogenous peptides will have broad application foreground.Here,we make a brief description on the birth and function of peptide,and focus on its new discovery and research progress to provide reference for endogenous peptides research.
Key words
peptide /
intracellular peptide /
body fluids endogenous peptides /
mode of action
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Yoshikawa M.Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects[J].Peptides,2015,72:208-225.
[2] Ferro ES,Rioli V,Castro LM,et al.Intracellular peptides:From discovery to function[J].Eupa Open Proteomics,2014,3:143-151.
[3] Livneh I,Cohen-Kaplan V,Cohen-Rosenzweig C,et al.The life cycle of the 26S proteasome:from birth,through regulation and function,and onto its death[J].Cell Res,2016,26(8):869-885.
[4] Berti DA,Russo LC,Castro LM,et al.Identification of intracellular peptides in rat adipose tissue:Insights into insulin resistance[J].Proteomics,2012,12(17):2668-2681.
[5] Dallas DC,Murray NM,Gan J.Proteolytic systems in milk:perspectives on the evolutionary function within the mammary gland and the infant[J].J Mammary Gland Biol Neoplasia,2015,20(3-4):133-147.
[6] Wan J,Cui XW,Zhang J,et al.Peptidome analysis of human skim milk in term and preterm milk[J].Biochem Biophys Res Commun,2013,438(1):236-241.
[7] Lauressergues D,Couzigou JM,Clemente HS,et al.Primary transcripts of microRNAs encode regulatory peptides[J].Nature,2015,520(7545):90-93.
[8] Lee C,Zeng J,Drew BG,et al.The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance[J].Cell Metab,2015,21(3):443-454.
[9] Romere C,Duerrschmid C,Bournat J,et al.Asprosin,a fasting-induced glucogenic protein hormone[J].Cell,2016,165(3):566-579.
[10] Sun W,Julie Li YS,Huang HD,et al.microRNA:a master regulator of cellular processes for bioengineering systems[J].Annu Rev Biomed Eng,2010,12:1-27.
PDF(329 KB)
